Genetic effects of benzene and radiation in ICR and X Gf mice

B. L. Harper, V. M.S. Ramanujam, L. Kurosky, M. S. Legator

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

X Gf mice (a tumor-resistant strain) were compared with ICR mice (moderately tumorsensitive) for their sensitivity to chromosomal damage caused by benzene, cyclophosphamide (CP), benzo(a)pyrene (BP) and radiation. There was no difference between strains in the level of micronucleus formation caused by BP, CP or radiation. Although X Gf mice metabolized somewhat less of the dose of benzene per weight than ICR mice, and had some-what higher levels of genetic damage, it is not known whether X Gf mice would be measurably more resistant to benzene carcinogenicity. Short-term genotoxicity tests are used as indicators of initiation, therefore, equal sensitivity to a set of standard clastogens suggests that tumor resistance in X Gf mice is a function of later stages of carcinogenesis.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalCancer Letters
Volume48
Issue number1
DOIs
StatePublished - Nov 15 1989

Keywords

  • X Gf mice
  • benzene
  • chromosomes
  • radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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