Genetic evaluation of suspected cases of transient HIV-1 infection of infants

Lisa M. Frenkel; James I. Mullins; Gerald H. Learn; Laura Manns-Arcuino; Belinda L. Herring; Marcia L. Kalish; Richard W. Steketee; Donald M. Thea; Joan E. Nichols; Shan Lu Liu; Abdallah Harmache; Xi He; David Muthui; Anup Madan; Leroy Hood; Ashley T. Haase; Mary Zupancic; Katherine Staskus; Steven Wolinsky; Paul Krogstad; Jia Qi Zhao; Irvin Chen; Richard Koup; David Ho; Bette Korber; Raymond J. Apple; Robert W. Coombs; Savita Pahwa; Norbert J. Roberts

doi:10.1126/science.280.5366.1073

Genetic evaluation of suspected cases of transient HIV-1 infection of infants

Lisa M. Frenkel
, James I. Mullins
, Gerald H. Learn
, Laura Manns-Arcuino
, Belinda L. Herring
, Marcia L. Kalish
, Richard W. Steketee
, Donald M. Thea
, Joan E. Nichols
, Shan Lu Liu
, Abdallah Harmache
, Xi He
, David Muthui
, Anup Madan
, Leroy Hood
, Ashley T. Haase
, Mary Zupancic
, Katherine Staskus
, Steven Wolinsky
, Paul Krogstad

Jia Qi Zhao, Irvin Chen, Richard Koup, David Ho, Bette Korber, Raymond J. Apple, Robert W. Coombs, Savita Pahwa, Norbert J. Roberts

Internal Medicine

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

Original language	English (US)
Pages (from-to)	1073-1077
Number of pages	5
Journal	Science
Volume	280
Issue number	5366
DOIs	https://doi.org/10.1126/science.280.5366.1073
State	Published - May 15 1998

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Frenkel, L. M., Mullins, J. I., Learn, G. H., Manns-Arcuino, L., Herring, B. L., Kalish, M. L., Steketee, R. W., Thea, D. M., Nichols, J. E., Liu, S. L., Harmache, A., He, X., Muthui, D., Madan, A., Hood, L., Haase, A. T., Zupancic, M., Staskus, K., Wolinsky, S., ... Roberts, N. J. (1998). Genetic evaluation of suspected cases of transient HIV-1 infection of infants. Science, 280(5366), 1073-1077. https://doi.org/10.1126/science.280.5366.1073

Frenkel, LM, Mullins, JI, Learn, GH, Manns-Arcuino, L, Herring, BL, Kalish, ML, Steketee, RW, Thea, DM, Nichols, JE, Liu, SL, Harmache, A, He, X, Muthui, D, Madan, A, Hood, L, Haase, AT, Zupancic, M, Staskus, K, Wolinsky, S, Krogstad, P, Zhao, JQ, Chen, I, Koup, R, Ho, D, Korber, B, Apple, RJ, Coombs, RW, Pahwa, S & Roberts, NJ 1998, 'Genetic evaluation of suspected cases of transient HIV-1 infection of infants', Science, vol. 280, no. 5366, pp. 1073-1077. https://doi.org/10.1126/science.280.5366.1073

@article{4a8a2e6c279e4b1dbe27e7db5a9b3898,

title = "Genetic evaluation of suspected cases of transient HIV-1 infection of infants",

abstract = "Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.",

author = "Frenkel, \{Lisa M.\} and Mullins, \{James I.\} and Learn, \{Gerald H.\} and Laura Manns-Arcuino and Herring, \{Belinda L.\} and Kalish, \{Marcia L.\} and Steketee, \{Richard W.\} and Thea, \{Donald M.\} and Nichols, \{Joan E.\} and Liu, \{Shan Lu\} and Abdallah Harmache and Xi He and David Muthui and Anup Madan and Leroy Hood and Haase, \{Ashley T.\} and Mary Zupancic and Katherine Staskus and Steven Wolinsky and Paul Krogstad and Zhao, \{Jia Qi\} and Irvin Chen and Richard Koup and David Ho and Bette Korber and Apple, \{Raymond J.\} and Coombs, \{Robert W.\} and Savita Pahwa and Roberts, \{Norbert J.\}",

year = "1998",

month = may,

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doi = "10.1126/science.280.5366.1073",

language = "English (US)",

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AU - Frenkel, Lisa M.

AU - Mullins, James I.

AU - Learn, Gerald H.

AU - Manns-Arcuino, Laura

AU - Herring, Belinda L.

AU - Kalish, Marcia L.

AU - Steketee, Richard W.

AU - Thea, Donald M.

AU - Nichols, Joan E.

AU - Liu, Shan Lu

AU - Harmache, Abdallah

AU - He, Xi

AU - Muthui, David

AU - Madan, Anup

AU - Hood, Leroy

AU - Haase, Ashley T.

AU - Zupancic, Mary

AU - Staskus, Katherine

AU - Wolinsky, Steven

AU - Krogstad, Paul

AU - Zhao, Jia Qi

AU - Chen, Irvin

AU - Koup, Richard

AU - Ho, David

AU - Korber, Bette

AU - Apple, Raymond J.

AU - Coombs, Robert W.

AU - Pahwa, Savita

AU - Roberts, Norbert J.

PY - 1998/5/15

Y1 - 1998/5/15

N2 - Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

AB - Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

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SP - 1073

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Genetic evaluation of suspected cases of transient HIV-1 infection of infants

Abstract

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