Genetic evidence for the involvement of Fcγ receptor III in experimental autoimmune myasthenia gravis pathogenesis

Erdem Tüzün, Shamsher S. Saini, Huan Yang, Dhivyaa Alagappan, Stephen Higgs, Premkumar Christadoss

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Immune complexes and classical complement pathway play vital roles in experimental autoimmune myasthenia gravis (EAMG). To analyze the role of immune complex receptors in EAMG, FcγRIII knockout (KO) mice were immunized with AChR and were found out to be resistant to EAMG induction. This was associated with reduced neuromuscular junction deposits, lymph node cell (LNC) IL-6 production and serum complement levels. EAMG resistance of anti-C1q Ab-administered mice was also associated with reduced LNC IL-6 production and neuromuscular junction deposits, indicating C1q involvement in EAMG resistance. The data provide the first direct genetic evidence for Fcγ receptor involvement in EAMG pathogenesis.

Original languageEnglish (US)
Pages (from-to)157-167
Number of pages11
JournalJournal of Neuroimmunology
Volume174
Issue number1-2
DOIs
StatePublished - May 2006

Fingerprint

Autoimmune Experimental Myasthenia Gravis
Fc Receptors
Neuromuscular Junction
Antigen-Antibody Complex
Interleukin-6
Lymph Nodes
Classical Complement Pathway
Knockout Mice
Serum

Keywords

  • Autoimmunity
  • C1q
  • Experimental autoimmune myasthenia gravis
  • Fc receptors
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Genetic evidence for the involvement of Fcγ receptor III in experimental autoimmune myasthenia gravis pathogenesis. / Tüzün, Erdem; Saini, Shamsher S.; Yang, Huan; Alagappan, Dhivyaa; Higgs, Stephen; Christadoss, Premkumar.

In: Journal of Neuroimmunology, Vol. 174, No. 1-2, 05.2006, p. 157-167.

Research output: Contribution to journalArticle

Tüzün, Erdem ; Saini, Shamsher S. ; Yang, Huan ; Alagappan, Dhivyaa ; Higgs, Stephen ; Christadoss, Premkumar. / Genetic evidence for the involvement of Fcγ receptor III in experimental autoimmune myasthenia gravis pathogenesis. In: Journal of Neuroimmunology. 2006 ; Vol. 174, No. 1-2. pp. 157-167.
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