Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness

S. T. Nichol, C. F. Spiropoulou, S. Morzunov, P. E. Rollin, Thomas Ksiazek, H. Feldmann, A. Sanchez, J. Childs, S. Zaki, C. J. Peters

Research output: Contribution to journalArticle

859 Citations (Scopus)

Abstract

A mysterious respiratory illness with high mortality was recently reported in the southwestern United States. Serologic studies implicated the hantaviruses, rodent-borne RNA viruses usually associated elsewhere in the world with hemorrhagic fever with renal syndrome. A genetic detection assay amplified hantavirus-specific DNA fragments from RNA extracted from the tissues of patients and deer mice (Peromyscus maniculatus) caught at or near patient residences. Nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.

Original languageEnglish (US)
Pages (from-to)914-917
Number of pages4
JournalScience
Volume262
Issue number5135
StatePublished - Nov 5 1993
Externally publishedYes

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Hantavirus
Peromyscus
Disease Outbreaks
Southwestern United States
Hemorrhagic Fever with Renal Syndrome
Satellite Viruses
RNA Viruses
Sequence Analysis
Rodentia
RNA
Mortality
DNA
Infection

ASJC Scopus subject areas

  • General

Cite this

Nichol, S. T., Spiropoulou, C. F., Morzunov, S., Rollin, P. E., Ksiazek, T., Feldmann, H., ... Peters, C. J. (1993). Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science, 262(5135), 914-917.

Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. / Nichol, S. T.; Spiropoulou, C. F.; Morzunov, S.; Rollin, P. E.; Ksiazek, Thomas; Feldmann, H.; Sanchez, A.; Childs, J.; Zaki, S.; Peters, C. J.

In: Science, Vol. 262, No. 5135, 05.11.1993, p. 914-917.

Research output: Contribution to journalArticle

Nichol, ST, Spiropoulou, CF, Morzunov, S, Rollin, PE, Ksiazek, T, Feldmann, H, Sanchez, A, Childs, J, Zaki, S & Peters, CJ 1993, 'Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness', Science, vol. 262, no. 5135, pp. 914-917.
Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek T, Feldmann H et al. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science. 1993 Nov 5;262(5135):914-917.
Nichol, S. T. ; Spiropoulou, C. F. ; Morzunov, S. ; Rollin, P. E. ; Ksiazek, Thomas ; Feldmann, H. ; Sanchez, A. ; Childs, J. ; Zaki, S. ; Peters, C. J. / Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. In: Science. 1993 ; Vol. 262, No. 5135. pp. 914-917.
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