Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness

Stuart T. Nichol; Christina F. Spiropoulou; Sergey Morzunov; Pierre E. Rollin; Thomas G. Ksiazek; Heinz Feldmann; Anthony Sanchez; James Childs; Sherif Zaki; Clarence J. Peters

doi:10.1126/science.8235615

Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness

Stuart T. Nichol, Christina F. Spiropoulou, Sergey Morzunov, Pierre E. Rollin, Thomas G. Ksiazek, Heinz Feldmann, Anthony Sanchez, James Childs, Sherif Zaki, Clarence J. Peters

Research output: Contribution to journal › Article › peer-review

988 Scopus citations

Abstract

A mysterious respiratory illness with high mortality was recently reported in the southwestern United States. Serologic studies implicated the hantaviruses, rodent-borne RNA viruses usually associated elsewhere in the world with hemorrhagic fever with renal syndrome. A genetic detection assay amplified hantavirus-specific DNA fragments from RNA extracted from the tissues of patients and deer mice (Peromyscus maniculatus) caught at or near patient residences. Nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.

Original language	English (US)
Pages (from-to)	914-917
Number of pages	4
Journal	Science
Volume	262
Issue number	5135
DOIs	https://doi.org/10.1126/science.8235615
State	Published - 1993
Externally published	Yes

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title = "Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness",

abstract = "A mysterious respiratory illness with high mortality was recently reported in the southwestern United States. Serologic studies implicated the hantaviruses, rodent-borne RNA viruses usually associated elsewhere in the world with hemorrhagic fever with renal syndrome. A genetic detection assay amplified hantavirus-specific DNA fragments from RNA extracted from the tissues of patients and deer mice (Peromyscus maniculatus) caught at or near patient residences. Nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.",

author = "Nichol, {Stuart T.} and Spiropoulou, {Christina F.} and Sergey Morzunov and Rollin, {Pierre E.} and Ksiazek, {Thomas G.} and Heinz Feldmann and Anthony Sanchez and James Childs and Sherif Zaki and Peters, {Clarence J.}",

year = "1993",

doi = "10.1126/science.8235615",

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T1 - Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness

AU - Nichol, Stuart T.

AU - Spiropoulou, Christina F.

AU - Morzunov, Sergey

AU - Rollin, Pierre E.

AU - Ksiazek, Thomas G.

AU - Feldmann, Heinz

AU - Sanchez, Anthony

AU - Childs, James

AU - Zaki, Sherif

AU - Peters, Clarence J.

PY - 1993

Y1 - 1993

N2 - A mysterious respiratory illness with high mortality was recently reported in the southwestern United States. Serologic studies implicated the hantaviruses, rodent-borne RNA viruses usually associated elsewhere in the world with hemorrhagic fever with renal syndrome. A genetic detection assay amplified hantavirus-specific DNA fragments from RNA extracted from the tissues of patients and deer mice (Peromyscus maniculatus) caught at or near patient residences. Nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.

AB - A mysterious respiratory illness with high mortality was recently reported in the southwestern United States. Serologic studies implicated the hantaviruses, rodent-borne RNA viruses usually associated elsewhere in the world with hemorrhagic fever with renal syndrome. A genetic detection assay amplified hantavirus-specific DNA fragments from RNA extracted from the tissues of patients and deer mice (Peromyscus maniculatus) caught at or near patient residences. Nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.

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ER -

Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness

Abstract

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