Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness

Stuart T. Nichol, Christina F. Spiropoulou, Sergey Morzunov, Pierre E. Rollin, Thomas G. Ksiazek, Heinz Feldmann, Anthony Sanchez, James Childs, Sherif Zaki, Clarence J. Peters

Research output: Contribution to journalArticle

875 Scopus citations

Abstract

A mysterious respiratory illness with high mortality was recently reported in the southwestern United States. Serologic studies implicated the hantaviruses, rodent-borne RNA viruses usually associated elsewhere in the world with hemorrhagic fever with renal syndrome. A genetic detection assay amplified hantavirus-specific DNA fragments from RNA extracted from the tissues of patients and deer mice (Peromyscus maniculatus) caught at or near patient residences. Nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.

Original languageEnglish (US)
Pages (from-to)914-917
Number of pages4
JournalScience
Volume262
Issue number5135
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Nichol, S. T., Spiropoulou, C. F., Morzunov, S., Rollin, P. E., Ksiazek, T. G., Feldmann, H., Sanchez, A., Childs, J., Zaki, S., & Peters, C. J. (1993). Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science, 262(5135), 914-917. https://doi.org/10.1126/science.8235615