Genetic Mapping of Two Mouse Homeobox Genes Tlx-1 and Tlx-2 to Murine Chromosomes 19 and 6

Xiao Yan Wen, Shaojun Tang, Martin L. Breitman

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We have previously cloned two mouse homeobox genes Tlx-1 (T-cell leukemia homeobox gene-1) and a related gene Tlx-2 based on their homology to human HOX11, a putative proto-oncogene involved in human T-cell leukemia. We have mapped Tlx-1 to mouse chromosome 19 and Tlx-2 to chromosome 6 by linkage analysis using an interspecific backcross (C57BL/6J × Mus spretus) F1 × M. spretus. The proposed gene orders and genetic distances for Tlx-1 and Tlx-2 are centromere 19-Lpc-1-(25.53 cM)-Pltr-4-(5.32 cM)-Tlx-1-(3.19 cM)-Ins-1-(7.45 cM)-Xmv-18, and centromere 6-Tcrb-(12.90 cM)-Mltr-3-(10.75 cM)-Tlx-2-(18.42 cM)-Xmv-6.

Original languageEnglish (US)
Pages (from-to)388-390
Number of pages3
JournalGenomics
Volume24
Issue number2
DOIs
StatePublished - Nov 15 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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