Genetic regulation of amniotic fluid TNF-alpha and soluble TNF receptor concentrations affected by race and preterm birth

Ramkumar Menon, Digna R. Velez, Nicole Morgan, Salvatore J. Lombardi, Stephen J. Fortunato, Scott M. Williams

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Racial disparity in spontaneous preterm birth (PTB) between African Americans and Caucasians in the US is unexplained, but is probably related to differences in amniotic fluid (AF) inflammatory cytokine profiles. Therefore, this study analyzed the association of 34 single nucleotide polymorphisms (SNPs) in TNF-α and its receptor genes (TNFR1 and TNFR2) with AF TNF-α and soluble TNF receptor (R1 and R2) concentrations in PTB. Samples consisted of African American and Caucasian cases (PTB), and controls (term birth) for which both cytokine, and maternal and fetal genotype data were available. Analyses were performed with genotype, case, and maker-status interaction in the model for log transformed cytokine concentrations. In Caucasians, two interactions between genotype and pregnancy outcome associated with cytokine concentrations, whereas 14 gene variants in African Americans showed interactions with pregnancy outcome, and 13 showed association with genetic markers. In conclusion, cytokine concentrations in African American preterm births can be partially explained by interactions between pregnancy outcome, SNPs and infection. This does not appear to be the case in Caucasians. These findings may be important in understanding disparity in rates of PTB between the two populations.

Original languageEnglish (US)
Pages (from-to)243-253
Number of pages11
JournalHuman Genetics
Volume124
Issue number3
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Tumor Necrosis Factor Receptors
Premature Birth
Amniotic Fluid
Tumor Necrosis Factor-alpha
African Americans
Cytokines
Pregnancy Outcome
Receptors, Tumor Necrosis Factor, Type II
Genotype
Single Nucleotide Polymorphism
Term Birth
Receptors, Tumor Necrosis Factor, Type I
Contraception
Genetic Markers
Genes
Mothers
Infection
Population

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Genetic regulation of amniotic fluid TNF-alpha and soluble TNF receptor concentrations affected by race and preterm birth. / Menon, Ramkumar; Velez, Digna R.; Morgan, Nicole; Lombardi, Salvatore J.; Fortunato, Stephen J.; Williams, Scott M.

In: Human Genetics, Vol. 124, No. 3, 2008, p. 243-253.

Research output: Contribution to journalArticle

Menon, Ramkumar ; Velez, Digna R. ; Morgan, Nicole ; Lombardi, Salvatore J. ; Fortunato, Stephen J. ; Williams, Scott M. / Genetic regulation of amniotic fluid TNF-alpha and soluble TNF receptor concentrations affected by race and preterm birth. In: Human Genetics. 2008 ; Vol. 124, No. 3. pp. 243-253.
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