Genetic regulation of testosterone-induced immune suppression

S. Ansar Ahmed; N. Talal; P. Christadoss

doi:10.1016/0008-8749(87)90009-8

Genetic regulation of testosterone-induced immune suppression

S. Ansar Ahmed
, N. Talal
, P. Christadoss

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Genes in the major histocompatibility complex (H-2) of the mouse control several immune functions as well as various facets of testosterone (Te) physiology. In order to study the genetic control of Te-induced immune suppression, complete Freund's adjuvant (CFA; containing Mycobacteria tuberculosis) was administered parenterally to several mouse strains differing at the H-2 complex which were either sham- or Te-treated. The specific lymphocyte proliferative response to purified protein derivative (PPD) was measured in draining lymph node cells. The response to PPD in strains bearing H-2^b (B6 and B10) but not H-2^d (B10.D2 and DBA/2) or H-2^k (B10.BR and AKR) haplotypes was markedly lower in Te-implanted compared to shamimplanted controls. This result suggests that the ability of Te to dampen the immune response to PPD is regulated by H-2-linked gene(s).

Original language	English (US)
Pages (from-to)	91-98
Number of pages	8
Journal	Cellular Immunology
Volume	104
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(87)90009-8
State	Published - Jan 1987
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(87)90009-8

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title = "Genetic regulation of testosterone-induced immune suppression",

abstract = "Genes in the major histocompatibility complex (H-2) of the mouse control several immune functions as well as various facets of testosterone (Te) physiology. In order to study the genetic control of Te-induced immune suppression, complete Freund's adjuvant (CFA; containing Mycobacteria tuberculosis) was administered parenterally to several mouse strains differing at the H-2 complex which were either sham- or Te-treated. The specific lymphocyte proliferative response to purified protein derivative (PPD) was measured in draining lymph node cells. The response to PPD in strains bearing H-2b (B6 and B10) but not H-2d (B10.D2 and DBA/2) or H-2k (B10.BR and AKR) haplotypes was markedly lower in Te-implanted compared to shamimplanted controls. This result suggests that the ability of Te to dampen the immune response to PPD is regulated by H-2-linked gene(s).",

author = "Ahmed, \{S. Ansar\} and N. Talal and P. Christadoss",

note = "Funding Information: These studies were supported in part by the NIH Multiple Arthritis Center and the General Medical Research Service of the Veterans{\textquoteright} Administration. Authors gratefully thank Mr. Sam Munro, Miss Iris Montoya, and Mr. David Reichert for their excellent technical assistance and Ms. Ann Kirkland and Mrs. Ethel Kern for their superb secretarial assistance.",

year = "1987",

month = jan,

doi = "10.1016/0008-8749(87)90009-8",

language = "English (US)",

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pages = "91--98",

journal = "Cellular Immunology",

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T1 - Genetic regulation of testosterone-induced immune suppression

AU - Ahmed, S. Ansar

AU - Talal, N.

AU - Christadoss, P.

N1 - Funding Information: These studies were supported in part by the NIH Multiple Arthritis Center and the General Medical Research Service of the Veterans’ Administration. Authors gratefully thank Mr. Sam Munro, Miss Iris Montoya, and Mr. David Reichert for their excellent technical assistance and Ms. Ann Kirkland and Mrs. Ethel Kern for their superb secretarial assistance.

PY - 1987/1

Y1 - 1987/1

N2 - Genes in the major histocompatibility complex (H-2) of the mouse control several immune functions as well as various facets of testosterone (Te) physiology. In order to study the genetic control of Te-induced immune suppression, complete Freund's adjuvant (CFA; containing Mycobacteria tuberculosis) was administered parenterally to several mouse strains differing at the H-2 complex which were either sham- or Te-treated. The specific lymphocyte proliferative response to purified protein derivative (PPD) was measured in draining lymph node cells. The response to PPD in strains bearing H-2b (B6 and B10) but not H-2d (B10.D2 and DBA/2) or H-2k (B10.BR and AKR) haplotypes was markedly lower in Te-implanted compared to shamimplanted controls. This result suggests that the ability of Te to dampen the immune response to PPD is regulated by H-2-linked gene(s).

AB - Genes in the major histocompatibility complex (H-2) of the mouse control several immune functions as well as various facets of testosterone (Te) physiology. In order to study the genetic control of Te-induced immune suppression, complete Freund's adjuvant (CFA; containing Mycobacteria tuberculosis) was administered parenterally to several mouse strains differing at the H-2 complex which were either sham- or Te-treated. The specific lymphocyte proliferative response to purified protein derivative (PPD) was measured in draining lymph node cells. The response to PPD in strains bearing H-2b (B6 and B10) but not H-2d (B10.D2 and DBA/2) or H-2k (B10.BR and AKR) haplotypes was markedly lower in Te-implanted compared to shamimplanted controls. This result suggests that the ability of Te to dampen the immune response to PPD is regulated by H-2-linked gene(s).

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DO - 10.1016/0008-8749(87)90009-8

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VL - 104

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JO - Cellular Immunology

JF - Cellular Immunology

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Genetic regulation of testosterone-induced immune suppression

Abstract

ASJC Scopus subject areas

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