Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses

M. W. Cloyd, J. W. Hartley, W. P. Rowe

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The mink cell focus-inducing (MCF)-247 virus, originally isolated from an AKR thymoma, is lymphomagenic in AKR mice but not in the ecotropic virus-negative NFS mouse strain. Analysis of sensitivity to lymphoma-induction by AKR-247 MCF virus in genetic hybrids between these two strains showed that F1 mice inoculated as sucklings were uniformly sensitive, whereas those inoculated as weanlings were generally resistant. In NFS backcross mice inoculated as sucklings, inheritance and expression of endogenous ecotropic virus from AKR was an essential correlate of replication of MCF virus and subsequent development of lymphoma. However, one-third of the mice expressing ecotropic virus and replicating the inoculated MCF virus did not develop lymphoma. The results suggested that an additional gene that influenced development of lymphoma may be involved, and that mice inheriting both virus-inducing loci from AKR were more susceptible than those inheriting only one. These findings indicate that the causal role of ecotropic virus infection in spontaneous thymomagenesis in AKR mice involves not only the generation of leukemogenic MCF viruses but also the establishment of permissiveness for their growth.

Original languageEnglish (US)
Pages (from-to)450-458
Number of pages9
JournalJournal of Experimental Medicine
Volume154
Issue number2
StatePublished - 1981

Fingerprint

Mink Cell Focus-Inducing Viruses
AKR murine leukemia virus
Lymphoma
Inbred AKR Mouse
Viruses
Permissiveness
Thymoma
Virus Diseases
Retroviridae
Growth
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses. / Cloyd, M. W.; Hartley, J. W.; Rowe, W. P.

In: Journal of Experimental Medicine, Vol. 154, No. 2, 1981, p. 450-458.

Research output: Contribution to journalArticle

Cloyd, M. W. ; Hartley, J. W. ; Rowe, W. P. / Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses. In: Journal of Experimental Medicine. 1981 ; Vol. 154, No. 2. pp. 450-458.
@article{58319a7ee66a4269aad85993a401d212,
title = "Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses",
abstract = "The mink cell focus-inducing (MCF)-247 virus, originally isolated from an AKR thymoma, is lymphomagenic in AKR mice but not in the ecotropic virus-negative NFS mouse strain. Analysis of sensitivity to lymphoma-induction by AKR-247 MCF virus in genetic hybrids between these two strains showed that F1 mice inoculated as sucklings were uniformly sensitive, whereas those inoculated as weanlings were generally resistant. In NFS backcross mice inoculated as sucklings, inheritance and expression of endogenous ecotropic virus from AKR was an essential correlate of replication of MCF virus and subsequent development of lymphoma. However, one-third of the mice expressing ecotropic virus and replicating the inoculated MCF virus did not develop lymphoma. The results suggested that an additional gene that influenced development of lymphoma may be involved, and that mice inheriting both virus-inducing loci from AKR were more susceptible than those inheriting only one. These findings indicate that the causal role of ecotropic virus infection in spontaneous thymomagenesis in AKR mice involves not only the generation of leukemogenic MCF viruses but also the establishment of permissiveness for their growth.",
author = "Cloyd, {M. W.} and Hartley, {J. W.} and Rowe, {W. P.}",
year = "1981",
language = "English (US)",
volume = "154",
pages = "450--458",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "2",

}

TY - JOUR

T1 - Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses

AU - Cloyd, M. W.

AU - Hartley, J. W.

AU - Rowe, W. P.

PY - 1981

Y1 - 1981

N2 - The mink cell focus-inducing (MCF)-247 virus, originally isolated from an AKR thymoma, is lymphomagenic in AKR mice but not in the ecotropic virus-negative NFS mouse strain. Analysis of sensitivity to lymphoma-induction by AKR-247 MCF virus in genetic hybrids between these two strains showed that F1 mice inoculated as sucklings were uniformly sensitive, whereas those inoculated as weanlings were generally resistant. In NFS backcross mice inoculated as sucklings, inheritance and expression of endogenous ecotropic virus from AKR was an essential correlate of replication of MCF virus and subsequent development of lymphoma. However, one-third of the mice expressing ecotropic virus and replicating the inoculated MCF virus did not develop lymphoma. The results suggested that an additional gene that influenced development of lymphoma may be involved, and that mice inheriting both virus-inducing loci from AKR were more susceptible than those inheriting only one. These findings indicate that the causal role of ecotropic virus infection in spontaneous thymomagenesis in AKR mice involves not only the generation of leukemogenic MCF viruses but also the establishment of permissiveness for their growth.

AB - The mink cell focus-inducing (MCF)-247 virus, originally isolated from an AKR thymoma, is lymphomagenic in AKR mice but not in the ecotropic virus-negative NFS mouse strain. Analysis of sensitivity to lymphoma-induction by AKR-247 MCF virus in genetic hybrids between these two strains showed that F1 mice inoculated as sucklings were uniformly sensitive, whereas those inoculated as weanlings were generally resistant. In NFS backcross mice inoculated as sucklings, inheritance and expression of endogenous ecotropic virus from AKR was an essential correlate of replication of MCF virus and subsequent development of lymphoma. However, one-third of the mice expressing ecotropic virus and replicating the inoculated MCF virus did not develop lymphoma. The results suggested that an additional gene that influenced development of lymphoma may be involved, and that mice inheriting both virus-inducing loci from AKR were more susceptible than those inheriting only one. These findings indicate that the causal role of ecotropic virus infection in spontaneous thymomagenesis in AKR mice involves not only the generation of leukemogenic MCF viruses but also the establishment of permissiveness for their growth.

UR - http://www.scopus.com/inward/record.url?scp=0019402271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019402271&partnerID=8YFLogxK

M3 - Article

C2 - 7264563

AN - SCOPUS:0019402271

VL - 154

SP - 450

EP - 458

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 2

ER -