Genetic variation of Japanese encephalitis virus in nature

W. R. Chen, R. B. Tesh, R. Rico-Hesse

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Forty-six strains of Japanese encephalitis (JE) virus from a variety of geographic areas of in Asia were examined by primer-extension sequencing of the RNA template. A 240 nucleotide sequence from the pre-M gene region was selected for study because it provided sufficient information for determining genetic relationships among the virus isolates. Using 12% divergence as a cutoff point for virus relationships, the 46 isolates fell into three distinct genotypic groups. One genotypic group consisted of JE virus isolated from northern Thailand and Cambodia. A second group was composed of isolates from southern Thailand, Malaysia, Sarawak and Indonesia. The remainder of the isolates, from Japan, China, Taiwan, the Philippines, Sri Lanka, India and Nepal, made up a third group. The implications of these findings in relation to the epidemiology of JE are discussed. Results of this study demonstrate that the comparison of short nucleotide sequences can provide insight into JE virus evolution, transmission and, possibly, pathogenesis.

Original languageEnglish (US)
Pages (from-to)2915-2922
Number of pages8
JournalJournal of General Virology
Volume71
Issue number12
StatePublished - 1990
Externally publishedYes

Fingerprint

Japanese Encephalitis Virus
Malaysia
Thailand
Japanese Encephalitis
Cambodia
Japanese Encephalitis Viruses
Viruses
RNA Sequence Analysis
Sri Lanka
Nepal
Philippines
Indonesia
Taiwan
India
China
Japan
Epidemiology
Genes

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Chen, W. R., Tesh, R. B., & Rico-Hesse, R. (1990). Genetic variation of Japanese encephalitis virus in nature. Journal of General Virology, 71(12), 2915-2922.

Genetic variation of Japanese encephalitis virus in nature. / Chen, W. R.; Tesh, R. B.; Rico-Hesse, R.

In: Journal of General Virology, Vol. 71, No. 12, 1990, p. 2915-2922.

Research output: Contribution to journalArticle

Chen, WR, Tesh, RB & Rico-Hesse, R 1990, 'Genetic variation of Japanese encephalitis virus in nature', Journal of General Virology, vol. 71, no. 12, pp. 2915-2922.
Chen WR, Tesh RB, Rico-Hesse R. Genetic variation of Japanese encephalitis virus in nature. Journal of General Virology. 1990;71(12):2915-2922.
Chen, W. R. ; Tesh, R. B. ; Rico-Hesse, R. / Genetic variation of Japanese encephalitis virus in nature. In: Journal of General Virology. 1990 ; Vol. 71, No. 12. pp. 2915-2922.
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