Genetics of glioblastoma: A window into its imaging and histopathologic variability

Clifford J. Belden, Pablo A. Valdes, Cong Ran, David A. Pastel, Brent T. Harris, Camilo E. Fadul, Mark A. Israel, Keith Paulsen, David W. Roberts

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Glioblastoma is a highly malignant brain tumor that relentlessly defies therapy. Efforts over the past decade have begun to tease out the biochemical details that lead to its aggressive behavior and poor prognosis. There is hope that this new understanding will lead to improved treatment strategies for patients with glioblastoma, in the form of targeted, molecularly based therapies that are individualized to specific changes in individual tumors. However, these new therapies have the potential to fundamentally alter the biologic behavior of glioblastoma and, as a result, its imaging appearance. Knowledge about common genetic alterations and the resultant cellular and tissue changes (ie, induced angiogenesis and abnormal cell survival, proliferation, and invasion) in glioblastomas is important as a basis for understanding imaging findings before treatment. It is equally critical that radiologists understand which genetic pathway is targeted by each specific therapeutic agent or class of agents in order to accurately interpret changes in the imaging appearances of treated tumors.

Original languageEnglish (US)
Pages (from-to)1717-1740
Number of pages24
JournalRadiographics
Volume31
Issue number6
DOIs
StatePublished - Oct 2011
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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