Genome sequence and attenuating mutations in Nile virus isolate from Mexico

David W.C. Beasley, C. Todd Davis, Jose Estrada-Franco, Roberto Navarro-Lopes, Arturo Campomanes-Cortes, Robert B. Tesh, Scott C. Weaver, Alan D.T. Barrett

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.

Original languageEnglish (US)
Pages (from-to)2221-2224
Number of pages4
JournalEmerging infectious diseases
Volume10
Issue number12
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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