Genome sequence and attenuating mutations in Nile virus isolate from Mexico

David Beasley, C. Todd Davis, Jose Estrada-Franco, Roberto Navarro-Lopes, Arturo Campomanes-Cortes, Robert B. Tesh, Scott Weaver, Alan Barrett

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.

Original languageEnglish (US)
Pages (from-to)2221-2224
Number of pages4
JournalEmerging Infectious Diseases
Volume10
Issue number12
StatePublished - Dec 2004

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Mexico
Genome
Viruses
West Nile virus
Amino Acid Motifs
Mutation
Glycosylation
Virulence
Nucleotides
Amino Acids

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Beasley, D., Davis, C. T., Estrada-Franco, J., Navarro-Lopes, R., Campomanes-Cortes, A., Tesh, R. B., ... Barrett, A. (2004). Genome sequence and attenuating mutations in Nile virus isolate from Mexico. Emerging Infectious Diseases, 10(12), 2221-2224.

Genome sequence and attenuating mutations in Nile virus isolate from Mexico. / Beasley, David; Davis, C. Todd; Estrada-Franco, Jose; Navarro-Lopes, Roberto; Campomanes-Cortes, Arturo; Tesh, Robert B.; Weaver, Scott; Barrett, Alan.

In: Emerging Infectious Diseases, Vol. 10, No. 12, 12.2004, p. 2221-2224.

Research output: Contribution to journalArticle

Beasley, D, Davis, CT, Estrada-Franco, J, Navarro-Lopes, R, Campomanes-Cortes, A, Tesh, RB, Weaver, S & Barrett, A 2004, 'Genome sequence and attenuating mutations in Nile virus isolate from Mexico', Emerging Infectious Diseases, vol. 10, no. 12, pp. 2221-2224.
Beasley D, Davis CT, Estrada-Franco J, Navarro-Lopes R, Campomanes-Cortes A, Tesh RB et al. Genome sequence and attenuating mutations in Nile virus isolate from Mexico. Emerging Infectious Diseases. 2004 Dec;10(12):2221-2224.
Beasley, David ; Davis, C. Todd ; Estrada-Franco, Jose ; Navarro-Lopes, Roberto ; Campomanes-Cortes, Arturo ; Tesh, Robert B. ; Weaver, Scott ; Barrett, Alan. / Genome sequence and attenuating mutations in Nile virus isolate from Mexico. In: Emerging Infectious Diseases. 2004 ; Vol. 10, No. 12. pp. 2221-2224.
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