Genome sequence and attenuating mutations in Nile virus isolate from Mexico

David W.C. Beasley; C. Todd Davis; Jose Estrada-Franco; Roberto Navarro-Lopes; Arturo Campomanes-Cortes; Robert B. Tesh; Scott C. Weaver; Alan D.T. Barrett

doi:10.3201/eid1012.040647

Genome sequence and attenuating mutations in Nile virus isolate from Mexico

David W.C. Beasley
, C. Todd Davis
, Jose Estrada-Franco
, Roberto Navarro-Lopes
, Arturo Campomanes-Cortes
, Robert B. Tesh
, Scott C. Weaver
, Alan D.T. Barrett

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.

Original language	English (US)
Pages (from-to)	2221-2224
Number of pages	4
Journal	Emerging infectious diseases
Volume	10
Issue number	12
DOIs	https://doi.org/10.3201/eid1012.040647
State	Published - Dec 2004

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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title = "Genome sequence and attenuating mutations in Nile virus isolate from Mexico",

abstract = "The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42\%) and 4 amino acid (0.11\%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.",

author = "Beasley, \{David W.C.\} and Davis, \{C. Todd\} and Jose Estrada-Franco and Roberto Navarro-Lopes and Arturo Campomanes-Cortes and Tesh, \{Robert B.\} and Weaver, \{Scott C.\} and Barrett, \{Alan D.T.\}",

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AU - Beasley, David W.C.

AU - Davis, C. Todd

AU - Estrada-Franco, Jose

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AU - Campomanes-Cortes, Arturo

AU - Tesh, Robert B.

AU - Weaver, Scott C.

AU - Barrett, Alan D.T.

PY - 2004/12

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M3 - Article

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JO - Emerging infectious diseases

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Genome sequence and attenuating mutations in Nile virus isolate from Mexico

Abstract

ASJC Scopus subject areas

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