Genome structure of Ebola virus subtype Reston: Differences among Ebola subtypes

Tetsuro Ikegami, A. B. Calaor, M. E. Miranda, M. Niikura, M. Saijo, I. Kurane, Y. Yoshikawa, S. Morikawa

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We determined the complete genome sequence of Ebola virus subtype Reston (EBO-R) in the Philippines in 1996. The deduced transcriptional signals were highly conserved among Ebola viruses except for the stop signal of L genes. The intergenic regions were composed of 4 to 7 nucleotides, and of 2 characteristic overlaps and a long intergenic region. The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996.

Original languageEnglish (US)
Pages (from-to)2021-2027
Number of pages7
JournalArchives of Virology
Volume146
Issue number10
DOIs
StatePublished - 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics
  • Applied Microbiology and Biotechnology

Cite this

Ikegami, T., Calaor, A. B., Miranda, M. E., Niikura, M., Saijo, M., Kurane, I., Yoshikawa, Y., & Morikawa, S. (2001). Genome structure of Ebola virus subtype Reston: Differences among Ebola subtypes. Archives of Virology, 146(10), 2021-2027. https://doi.org/10.1007/s007050170049