Genome structure of Ebola virus subtype Reston: Differences among Ebola subtypes

T. Ikegami; A. B. Calaor; M. E. Miranda; M. Niikura; M. Saijo; I. Kurane; Y. Yoshikawa; S. Morikawa

doi:10.1007/s007050170049

Genome structure of Ebola virus subtype Reston: Differences among Ebola subtypes

T. Ikegami
, A. B. Calaor
, M. E. Miranda
, M. Niikura
, M. Saijo
, I. Kurane
, Y. Yoshikawa
, S. Morikawa

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We determined the complete genome sequence of Ebola virus subtype Reston (EBO-R) in the Philippines in 1996. The deduced transcriptional signals were highly conserved among Ebola viruses except for the stop signal of L genes. The intergenic regions were composed of 4 to 7 nucleotides, and of 2 characteristic overlaps and a long intergenic region. The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996.

Original language	English (US)
Pages (from-to)	2021-2027
Number of pages	7
Journal	Archives of virology
Volume	146
Issue number	10
DOIs	https://doi.org/10.1007/s007050170049
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Virology

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10.1007/s007050170049

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T2 - Differences among Ebola subtypes

AU - Ikegami, T.

AU - Calaor, A. B.

AU - Miranda, M. E.

AU - Niikura, M.

AU - Saijo, M.

AU - Kurane, I.

AU - Yoshikawa, Y.

AU - Morikawa, S.

PY - 2001

Y1 - 2001

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AB - We determined the complete genome sequence of Ebola virus subtype Reston (EBO-R) in the Philippines in 1996. The deduced transcriptional signals were highly conserved among Ebola viruses except for the stop signal of L genes. The intergenic regions were composed of 4 to 7 nucleotides, and of 2 characteristic overlaps and a long intergenic region. The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996.

UR - https://www.scopus.com/pages/publications/0034752809

UR - https://www.scopus.com/pages/publications/0034752809#tab=citedBy

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SP - 2021

EP - 2027

JO - Archives of virology

JF - Archives of virology

IS - 10

ER -

Genome structure of Ebola virus subtype Reston: Differences among Ebola subtypes

Abstract

ASJC Scopus subject areas

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