Genomic characterization and evolution of Tacaiuma orthobunyavirus (Peribunyaviridae family) isolated in Brazil

Aristides Bezerra de Melo, William Marciel de Souza, Gustavo Olszanski Acrani, Valéria Lima Carvalho, Marilia Farignoli Romeiro, Aline Lavado Tolardo, Sandro Patroca da Silva, Jedson Ferreira Cardoso, Jannifer de Oliveira Chiang, João Lídio da Silva Gonçalves Vianez, Raimunda do Socorro da Silva Azevedo, Luiz Tadeu Moraes Figueiredo, Pedro Fernando da Costa Vasconcelos, Márcio Roberto Teixeira Nunes, Daniele Barbosa de Almeida Medeiros

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Tacaiuma virus (TCMV) is antigenically characterized as a member of the Anopheles A complex in the Orthobunyavirus genus, Peribunyaviridae family (Bunyavirales order). Clinically, the TCMV infection is characterized by acute febrile illness with myalgia and arthralgia lasting three to five days. However, the genomic and evolutionary aspect of this virus has not been elucidated. In this study, we described the complete coding sequences of three segments of two TCMV strains isolated in Brazil and three complete coding sequences of the small segment of three TCMV strains. All the strains sequenced in this study showed the typical genomic organization of orthobunyaviruses that infect vertebrates, except for the absence of the open reading frame that encodes the well-described non-structural small protein. This study presents the genomic and evolutionary characterization of TCMV strains and would be helpful for diagnostic purposes and epidemiology.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalInfection, Genetics and Evolution
Volume60
DOIs
StatePublished - Jun 2018
Externally publishedYes

Keywords

  • Arbovirus
  • Bunyavirales
  • Genomic characterization
  • Orthobunyavirus
  • Tacaiuma orthobunyavirus

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

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