@article{f0586ece299149ed9231e721b134c6ba,
title = "Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014",
abstract = "Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease caused by CCHF virus (CCHFV). Ticks in the genus Hyalomma are the main vectors and reservoirs of CCHFV. In Spain, CCHFV was first detected in Hyalomma ticks from C{\'a}ceres in 2010. Subsequently, two autochthonous CCHF cases were reported in August 2016. In this study, we describe the characterization of the CCHFV genome directly from Hyalomma lusitanicum collected in C{\'a}ceres in 2014. Phylogenetic analyses reveal a close relationship with clade III strains from West Africa, with an estimated divergence time of 50 years. The results of this work suggest that CCHFV has been circulating in Spain for some time, and most likely originated from West Africa.",
keywords = "Crimean-Congo hemorrhagic fever (CCHF), Hyalomma tick, Spain, emerging disease, tick-borne disease",
author = "Cajimat, {Maria N.B.} and Rodriguez, {Sergio E.} and Schuster, {Isolde U.E.} and Swetnam, {Daniele M.} and Ksiazek, {Thomas G.} and Habela, {Miguel A.} and Negredo, {Ana Isabel} and Agust{\'i}n Estrada-Pe{\~n}a and Barrett, {Alan D.T.} and Bente, {Dennis A.}",
note = "Funding Information: Bayesian analyses suggest that C{\'a}ceres 2014 diverged from West African clade III viruses approximately five decades ago, and accordingly, CCHFV may have been in Spain for some time. This finding is supported by the detection of CCHFV RNA from Hyalomma ticks in four regions (Extremadura, Castilla-La Mancha, Castilla y Le{\'o}n, and Madrid) in Spain following the 2016 CCHF cases (Ministerio de Sanidad, Servicios Sociales e Igualdad 2017). The detection of antibodies to CCHFV in persons from Southern Portugal near the border with Spain in 1980 (Filipe et al. 1985) further suggests that CCHFV has been circulating silently in the Iberian Peninsula. Publisher Copyright: {\textcopyright} Copyright 2017, Mary Ann Liebert, Inc. 2017.",
year = "2017",
month = oct,
doi = "10.1089/vbz.2017.2190",
language = "English (US)",
volume = "17",
pages = "714--719",
journal = "Vector-Borne and Zoonotic Diseases",
issn = "1530-3667",
publisher = "Mary Ann Liebert Inc.",
number = "10",
}