Genomic characterization of yogue, kasokero, issyk-kul, keterah, gossas, and thiafora viruses: Nairoviruses naturally infecting bats, shrews, and ticks

Peter J. Walker, Steven Widen, Cadhla Firth, Kim R. Blasdell, Thomas Wood, Amelia P A Travassos Da Rosa, Hilda Guzman, Robert B. Tesh, Nikos Vasilakis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The genus Nairovirus of arthropod-borne bunyaviruses includes the important emerging human pathogen, Crimean-Congo hemorrhagic fever virus (CCHFV), as well as Nairobi sheep disease virus and many other poorly described viruses isolated frommammals, birds, and ticks.Here, we report genome sequence analysis of six nairoviruses: Thiafora virus (TFAV) that was isolated from a shrew in Senegal; Yogue (YOGV), Kasokero (KKOV), and Gossas (GOSV) viruses isolated from bats in Senegal and Uganda; Issyk-Kul virus (IKV) isolated from bats in Kyrgyzstan; and Keterah virus (KTRV) isolated from ticks infesting a bat in Malaysia. The S, M, and L genome segments of each virus were found to encode proteins corresponding to the nucleoprotein, polyglycoprotein, and polymerase protein of CCHFV. However, as observed in Leopards Hill virus (LPHV) and Erve virus (ERVV), polyglycoproteins encoded in the M segment lack sequences encoding the double-membrane-spanning CCHFV NSm protein. Amino acid sequence identities, complement-fixation tests, and phylogenetic analysis indicated that these viruses cluster into three groups comprising KKOV, YOGV, and LPHV from bats of the suborder Yingochiroptera; KTRV, IKV, and GOSV from bats of the suborder Yangochiroptera; and TFAV and ERVV from shrews (Soricomorpha: Soricidae). This reflects clade-specific host and vector associations that extend across the genus.

Original languageEnglish (US)
Pages (from-to)1041-1051
Number of pages11
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume93
Issue number5
DOIs
StatePublished - Nov 4 2015

Fingerprint

Nairovirus
Shrews
Ticks
Viruses
Crimean-Congo hemorrhagic fever virus
Panthera
Senegal
Nairobi sheep disease virus
Kyrgyzstan
Orthobunyavirus
Genome
Complement Fixation Tests
Proteins

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Genomic characterization of yogue, kasokero, issyk-kul, keterah, gossas, and thiafora viruses : Nairoviruses naturally infecting bats, shrews, and ticks. / Walker, Peter J.; Widen, Steven; Firth, Cadhla; Blasdell, Kim R.; Wood, Thomas; Travassos Da Rosa, Amelia P A; Guzman, Hilda; Tesh, Robert B.; Vasilakis, Nikos.

In: American Journal of Tropical Medicine and Hygiene, Vol. 93, No. 5, 04.11.2015, p. 1041-1051.

Research output: Contribution to journalArticle

Walker, Peter J. ; Widen, Steven ; Firth, Cadhla ; Blasdell, Kim R. ; Wood, Thomas ; Travassos Da Rosa, Amelia P A ; Guzman, Hilda ; Tesh, Robert B. ; Vasilakis, Nikos. / Genomic characterization of yogue, kasokero, issyk-kul, keterah, gossas, and thiafora viruses : Nairoviruses naturally infecting bats, shrews, and ticks. In: American Journal of Tropical Medicine and Hygiene. 2015 ; Vol. 93, No. 5. pp. 1041-1051.
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