Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women

Akanni Adededji Abdoul Ibitokou, Laurent Brutus, Bertin Vianou, Mayke Oesterholt, Achille Massougbodji, Philippe Deloron, Marita Troye-Blomberg, Nadine Fievet, Adrian J F Luty

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4+ T cells declined significantly, contrasting with a non-significant increase in CD8+ T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalJournal of Reproductive Immunology
Volume98
Issue number1-2
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Gestational Age
Blood Cells
T-Lymphocytes
Natural Killer T-Cells
Second Pregnancy Trimester
Antigen-Presenting Cells
Developed Countries
Natural Killer Cells
Longitudinal Studies
Flow Cytometry
Cohort Studies
Mothers
Pregnancy

Keywords

  • African women
  • Antigen-presenting cells
  • Longitudinal cohort study
  • Lymphocytes
  • Peripheral blood mononuclear cells
  • Pregnancy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Ibitokou, A. A. A., Brutus, L., Vianou, B., Oesterholt, M., Massougbodji, A., Deloron, P., ... Luty, A. J. F. (2013). Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women. Journal of Reproductive Immunology, 98(1-2), 21-28. https://doi.org/10.1016/j.jri.2013.03.002

Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women. / Ibitokou, Akanni Adededji Abdoul; Brutus, Laurent; Vianou, Bertin; Oesterholt, Mayke; Massougbodji, Achille; Deloron, Philippe; Troye-Blomberg, Marita; Fievet, Nadine; Luty, Adrian J F.

In: Journal of Reproductive Immunology, Vol. 98, No. 1-2, 2013, p. 21-28.

Research output: Contribution to journalArticle

Ibitokou, AAA, Brutus, L, Vianou, B, Oesterholt, M, Massougbodji, A, Deloron, P, Troye-Blomberg, M, Fievet, N & Luty, AJF 2013, 'Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women', Journal of Reproductive Immunology, vol. 98, no. 1-2, pp. 21-28. https://doi.org/10.1016/j.jri.2013.03.002
Ibitokou, Akanni Adededji Abdoul ; Brutus, Laurent ; Vianou, Bertin ; Oesterholt, Mayke ; Massougbodji, Achille ; Deloron, Philippe ; Troye-Blomberg, Marita ; Fievet, Nadine ; Luty, Adrian J F. / Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women. In: Journal of Reproductive Immunology. 2013 ; Vol. 98, No. 1-2. pp. 21-28.
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