Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women

Samad Ibitokou, Laurent Brutus, Bertin Vianou, Mayke Oesterholt, Achille Massougbodji, Philippe Deloron, Marita Troye-Blomberg, Nadine Fievet, Adrian J.F. Luty

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4+ T cells declined significantly, contrasting with a non-significant increase in CD8+ T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalJournal of Reproductive Immunology
Volume98
Issue number1-2
DOIs
StatePublished - Apr 29 2013

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Keywords

  • African women
  • Antigen-presenting cells
  • Longitudinal cohort study
  • Lymphocytes
  • Peripheral blood mononuclear cells
  • Pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Ibitokou, S., Brutus, L., Vianou, B., Oesterholt, M., Massougbodji, A., Deloron, P., Troye-Blomberg, M., Fievet, N., & Luty, A. J. F. (2013). Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women. Journal of Reproductive Immunology, 98(1-2), 21-28. https://doi.org/10.1016/j.jri.2013.03.002