TY - JOUR
T1 - Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women
AU - Ibitokou, Samad
AU - Brutus, Laurent
AU - Vianou, Bertin
AU - Oesterholt, Mayke
AU - Massougbodji, Achille
AU - Deloron, Philippe
AU - Troye-Blomberg, Marita
AU - Fievet, Nadine
AU - Luty, Adrian J.F.
N1 - Funding Information:
This paper describes work undertaken in the context of the STOPPAM project (‘Strategies To Prevent Pregnancy Associated Malaria’; http://www.stoppam.org ) and was supported financially by the European Union Framework 7 Programme , contract number: 200889 . This publication was made possible through support provided by the AIRD-DPF (PhD research grant to SI).
PY - 2013
Y1 - 2013
N2 - Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4+ T cells declined significantly, contrasting with a non-significant increase in CD8+ T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.
AB - Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4+ T cells declined significantly, contrasting with a non-significant increase in CD8+ T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.
KW - African women
KW - Antigen-presenting cells
KW - Longitudinal cohort study
KW - Lymphocytes
KW - Peripheral blood mononuclear cells
KW - Pregnancy
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U2 - 10.1016/j.jri.2013.03.002
DO - 10.1016/j.jri.2013.03.002
M3 - Article
C2 - 23628177
AN - SCOPUS:84877838678
SN - 0165-0378
VL - 98
SP - 21
EP - 28
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
IS - 1-2
ER -