Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women

Samad Ibitokou; Laurent Brutus; Bertin Vianou; Mayke Oesterholt; Achille Massougbodji; Philippe Deloron; Marita Troye-Blomberg; Nadine Fievet; Adrian J.F. Luty

doi:10.1016/j.jri.2013.03.002

Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women

Samad Ibitokou
, Laurent Brutus
, Bertin Vianou
, Mayke Oesterholt
, Achille Massougbodji
, Philippe Deloron
, Marita Troye-Blomberg
, Nadine Fievet
, Adrian J.F. Luty

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4⁺ T cells declined significantly, contrasting with a non-significant increase in CD8⁺ T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.

Original language	English (US)
Pages (from-to)	21-28
Number of pages	8
Journal	Journal of Reproductive Immunology
Volume	98
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jri.2013.03.002
State	Published - 2013
Externally published	Yes

Keywords

African women
Antigen-presenting cells
Longitudinal cohort study
Lymphocytes
Peripheral blood mononuclear cells
Pregnancy

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.jri.2013.03.002

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title = "Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women",

abstract = "Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4+ T cells declined significantly, contrasting with a non-significant increase in CD8+ T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.",

keywords = "African women, Antigen-presenting cells, Longitudinal cohort study, Lymphocytes, Peripheral blood mononuclear cells, Pregnancy",

author = "Samad Ibitokou and Laurent Brutus and Bertin Vianou and Mayke Oesterholt and Achille Massougbodji and Philippe Deloron and Marita Troye-Blomberg and Nadine Fievet and Luty, \{Adrian J.F.\}",

note = "Funding Information: This paper describes work undertaken in the context of the STOPPAM project ({\textquoteleft}Strategies To Prevent Pregnancy Associated Malaria{\textquoteright}; http://www.stoppam.org ) and was supported financially by the European Union Framework 7 Programme , contract number: 200889 . This publication was made possible through support provided by the AIRD-DPF (PhD research grant to SI). ",

year = "2013",

doi = "10.1016/j.jri.2013.03.002",

language = "English (US)",

volume = "98",

pages = "21--28",

journal = "Journal of Reproductive Immunology",

issn = "0165-0378",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women

AU - Ibitokou, Samad

AU - Brutus, Laurent

AU - Vianou, Bertin

AU - Oesterholt, Mayke

AU - Massougbodji, Achille

AU - Deloron, Philippe

AU - Troye-Blomberg, Marita

AU - Fievet, Nadine

AU - Luty, Adrian J.F.

N1 - Funding Information: This paper describes work undertaken in the context of the STOPPAM project (‘Strategies To Prevent Pregnancy Associated Malaria’; http://www.stoppam.org ) and was supported financially by the European Union Framework 7 Programme , contract number: 200889 . This publication was made possible through support provided by the AIRD-DPF (PhD research grant to SI).

PY - 2013

Y1 - 2013

N2 - Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4+ T cells declined significantly, contrasting with a non-significant increase in CD8+ T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.

AB - Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4+ T cells declined significantly, contrasting with a non-significant increase in CD8+ T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.

KW - African women

KW - Antigen-presenting cells

KW - Longitudinal cohort study

KW - Lymphocytes

KW - Peripheral blood mononuclear cells

KW - Pregnancy

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U2 - 10.1016/j.jri.2013.03.002

DO - 10.1016/j.jri.2013.03.002

M3 - Article

C2 - 23628177

AN - SCOPUS:84877838678

SN - 0165-0378

VL - 98

SP - 21

EP - 28

JO - Journal of Reproductive Immunology

JF - Journal of Reproductive Immunology

IS - 1-2

ER -

Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women

Abstract

Keywords

ASJC Scopus subject areas

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