Ginseng root: Evidence for numerous regulatory peptides and insulinotropic activity

Tao Zhang, Minoru Hosnmo, Kazuaki Iguchi, Junji Ishikawa, Tonnu Mochizuki, Naoki Takatsuka, Chizuko Yanaihara, Masami Yokota, George H. Greeley, Noboru Yanaihara

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations

    Abstract

    R The purpose of this study was to examine the presence of various regulatory peptides in ginseng root by means of different specific radioimmunoassays; and to examine the effect of ginseng root extracts on glucose-induced insulin release from the isolated perfused rat pancreas. Korea ginseng root powder was extracted with 1M acetic acid or 0.01 N HCl/ethanol (30/70, v/v). Radioimmunoassays of the extracts showed the presence of 3 fmol to 13 pmol immunoreactive prorenin, EGF (epidermal growth factor), galanin, VIP (vasoactive intestinal peptide), renin and PP (pancreatic polypeptide) in one gram ginseng root powder. An acetic acid extract of ginseng root powder was found to enhance glucose-induced insulin release from the isolated perfused rat pancreas. Fractionation ofthe ginseng extract on Sephadex G-25 chromatography showed that the insulinotropic activity was contained primarily in a fraction which contained VIP-like immunoreactivity. The present results suggest that ginseng root contains several biologically active peptides and that a VIP-like substance in ginseng root can enhance glucose-induced insulin release from the isolated perfused rat pancreas.

    Original languageEnglish (US)
    Pages (from-to)49-54
    Number of pages6
    JournalBiomedical Research (Japan)
    Volume11
    Issue number1
    DOIs
    StatePublished - Jan 1 1990

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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