Ginseng root: Evidence for numerous regulatory peptides and insulinotropic activity

T. Zhang, M. Hoshino, K. Iguchi, J. Ishikawa, T. Mochizuki, N. Takatsuka, C. Yanaihara, M. Yokota, G. H. Greeley, N. Yanaihara

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    The purpose of this study was to examine the presence of various regulatory peptides in ginseng root by means of different specific radioimmunoassays; and to examine the effect of ginseng root extracts on glucose-induced insulin release from the isolated perfused rat pancreas. Korea ginseng root powder was extracted with 1 M acetic acid or 0.01 N HCl/ethanol (30/70, v/v). Radioimmunoassays of the extracts showed the presence of 3 fmol to 13 pmol immunoreactive prorenin, EGF (epidermal growth factor), galanin, VIP (vasoactive intestinal peptide), renin and PP (pancreatic polypeptide) in one gram ginseng root powder. An acetic acid extract of ginseng root powder was found to enhance glucose-induced insulin release from the isolated perfused rat pancreas. Fractionation of the ginseng extract on Sephadex G-25 chromatography showed that the insulinotropic activity was contained primarily in a fraction which contained VIP-like immunoreactivity. The present results suggest that ginseng root contains several biologically active peptides and that a VIP-like substance in ginseng root can enhance glucose-induced insulin release from the isolated perfused rat pancreas.

    Original languageEnglish (US)
    Pages (from-to)49-54
    Number of pages6
    JournalBiomedical Research
    Volume11
    Issue number1
    StatePublished - 1990

    Fingerprint

    Panax
    Vasoactive Intestinal Peptide
    Powders
    Rats
    Insulin
    Renin
    Glucose
    Acetic Acid
    Peptides
    Galanin
    Pancreatic Polypeptide
    Fractionation
    Chromatography
    Epidermal Growth Factor
    Pancreas
    Ethanol
    Radioimmunoassay
    Korea

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Zhang, T., Hoshino, M., Iguchi, K., Ishikawa, J., Mochizuki, T., Takatsuka, N., ... Yanaihara, N. (1990). Ginseng root: Evidence for numerous regulatory peptides and insulinotropic activity. Biomedical Research, 11(1), 49-54.

    Ginseng root : Evidence for numerous regulatory peptides and insulinotropic activity. / Zhang, T.; Hoshino, M.; Iguchi, K.; Ishikawa, J.; Mochizuki, T.; Takatsuka, N.; Yanaihara, C.; Yokota, M.; Greeley, G. H.; Yanaihara, N.

    In: Biomedical Research, Vol. 11, No. 1, 1990, p. 49-54.

    Research output: Contribution to journalArticle

    Zhang, T, Hoshino, M, Iguchi, K, Ishikawa, J, Mochizuki, T, Takatsuka, N, Yanaihara, C, Yokota, M, Greeley, GH & Yanaihara, N 1990, 'Ginseng root: Evidence for numerous regulatory peptides and insulinotropic activity', Biomedical Research, vol. 11, no. 1, pp. 49-54.
    Zhang T, Hoshino M, Iguchi K, Ishikawa J, Mochizuki T, Takatsuka N et al. Ginseng root: Evidence for numerous regulatory peptides and insulinotropic activity. Biomedical Research. 1990;11(1):49-54.
    Zhang, T. ; Hoshino, M. ; Iguchi, K. ; Ishikawa, J. ; Mochizuki, T. ; Takatsuka, N. ; Yanaihara, C. ; Yokota, M. ; Greeley, G. H. ; Yanaihara, N. / Ginseng root : Evidence for numerous regulatory peptides and insulinotropic activity. In: Biomedical Research. 1990 ; Vol. 11, No. 1. pp. 49-54.
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