Glanders: Off to the races with Burkholderia mallei

Gregory C. Whitlock, D. Mark Estes, Alfredo G. Torres

Research output: Contribution to journalShort survey

97 Scopus citations

Abstract

Burkholderia mallei, the etiologic agent of the disease known as glanders, is primarily a disease affecting horses and is transmitted to humans by direct contact with infected animals. The use of B. mallei as a biological weapon has been reported and currently, there is no vaccine available for either humans or animals. Despite the history and highly infective nature of B. mallei, as well as its potential use as a bio-weapon, B. mallei research to understand the pathogenesis and the host responses to infection remains limited. Therefore, this minireview will focus on current efforts to elucidate B. mallei virulence, the associated host immune responses elicited during infection and discuss the feasibility of vaccine development.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalFEMS Microbiology Letters
Volume277
Issue number2
DOIs
StatePublished - Dec 1 2007

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Keywords

  • Burkholderia
  • Burkholderia mallei
  • Glanders
  • Immune responses
  • Virulence factors

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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