Glucagon-like peptide 2 is an endogenous mediator of postresection intestinal adaptation

Alexander Perez, Mark Duxbury, Flavio G. Rocha, Anthony P. Ramsanahie, Robert S. Farivar, Heike Varnholt, Hiromichi Ito, Helen Wong, Jan Rounds, Michael J. Zinner, Edward E. Whang, Stanley W. Ashley

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background: After massive small bowel resection, the remnant intestine undergoes compensatory adaptation. We tested the hypothesis that glucagon-like peptide-2 (GLP-2) is an endogenous mediator of postresection intestinal adaptation. Methods: Rats were allocated to 1 of 4 groups: groups 1 and 2 rats underwent mid-small bowel transection and reanastomosis; groups 3 and 4 rats underwent 75% mid-small bowel resection and reanastomosis. Groups 2 and 4 rats were administered 1.8 mg of antirat GLP-2 antibody twice daily beginning immediately after the surgical procedure; groups 1 and 3 rats were administered rabbit serum (control). Ileal specimens were harvested on postoperative day 7. Results: Heal mucosa from group 3 animals displayed morphologic and proliferative indices of adaptation. Each of these indices of adaptation was inhibited by GLP-2 immunoneutralization (group 4). Morphologic and proliferative parameters in the ileum from animals that had undergone transection with reanastomosis were unaffected by GLP-2 immunoneutralization. Conclusions: These results suggest that GLP-2 is an endogenous mediator of postresection intestinal adaptation.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalJournal of Parenteral and Enteral Nutrition
Volume29
Issue number2
DOIs
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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    Perez, A., Duxbury, M., Rocha, F. G., Ramsanahie, A. P., Farivar, R. S., Varnholt, H., Ito, H., Wong, H., Rounds, J., Zinner, M. J., Whang, E. E., & Ashley, S. W. (2005). Glucagon-like peptide 2 is an endogenous mediator of postresection intestinal adaptation. Journal of Parenteral and Enteral Nutrition, 29(2), 97-101. https://doi.org/10.1177/014860710502900297