Glucocorticoid receptor binding in three different cell types in major depressive disorder: Lack of evidence op receptor binding defect

Adel A. Wassef, Michael O'Boyle, Russell Gardner, Robert M. Rose, Alston Brown, Ann Harris, Hanh Nguyen, Walter J. Meyer

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

1. In order to further understand the apparent glucocorticoid resistance in major depressive disorder, circadian variation in cortisol concentration, dexamethasone suppression and glucocorticoid receptor binding in mononuclear leukocytes, polymorphonuclear leukocytes and cultured skin fibroblasts were measured in rigidly defined major depressive disorder patients and non-depressed psychiatric controls. 2. Mononuclear leukocytes binding to glucocorticoid correlated significantly with polymorphonuclear leukocytes binding to glucocorticoid, but both determinations failed to differentiate major depressive disorder and control subjects. 3. Initial and post-dexamethasone in vitro fibroblast binding to glucocorticoid was not different between major depressive disorder and non-depressed control subjects. 4. The phenomenon of glucocorticoid resistance in major depressive disorder remains unexplained.

Original languageEnglish (US)
Pages (from-to)65-78
Number of pages14
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume16
Issue number1
DOIs
StatePublished - Jan 1992

Keywords

  • cortisol
  • fibroblasts
  • glucocorticoid receptors
  • major depression
  • mononuclear leukocytes
  • polymorphonuclear leukocytes

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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