Glucose effects on the peritoneum: What can we learn from rodent models?

S. Müller-Krebs, W. Zhang, L. P. Kihm, J. Reiser, P. P. Nawroth, V. Schwenger

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


During long-term peritoneal dialysis (PD) the peritoneal membrane underlies processes of structural and functional reorganization mediated by high glucose and reactive glucose metabolites that are contained in PD solutions; this process is accompanied by increasing fibrosis. Mechanistically, the peritoneal damage is triggered by the interaction of advanced glycation end-products with their receptor; this is true for rodents as well as for humans. With this knowledge interventional strategies can be tested in rodent models, among them are the lipid soluble vitamin B1 analogue benfotiamine (BF) or detoxifying enzymes such as glyoxalase. Of additional interest is the finding that PD fluids do not only cause local but also systemic damage, in particular renal and cardiovascular. In the case of kidney damage, the intervention with BF was also successful. Taken together, PD can be regarded as a local model for long-term diabetes together with systemic aspects of damage.

Original languageEnglish (US)
Pages (from-to)197-198
Number of pages2
JournalExperimental and Clinical Endocrinology and Diabetes
Issue number4
StatePublished - 2012
Externally publishedYes


  • advanced glycation end-products
  • diabetes
  • glucose degradation products
  • local damage
  • peritoneum
  • reactive glucose metabolites

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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