Glutamate dehydrogenase in Reye's syndrome Evidence for the presence of an altered enzyme in serum with increased susceptibility to inhibition by GTP

Jeffrey T. Holt, Dean A. Arvan, Theodor Mayer, Thomas J. Smith, J. Ellis Bell

Research output: Contribution to journalArticle

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Abstract

The glutamate dehydrogenase activity found in the serum of patients with Reye's syndrome is shown to be inhibited about 1000-fold more potently by GTP than is the normal human enzyme. 1 mM ADP, which with the normal enzyme effectively reverse GTP inhibition, has no effect in the GTP inhibition of the Reye's syndrome serum activity.

Original languageEnglish (US)
Pages (from-to)42-46
Number of pages5
JournalBiochimica et Biophysica Acta (BBA)/Protein Structure and Molecular
Volume749
Issue number1
DOIs
StatePublished - Nov 28 1983
Externally publishedYes

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Keywords

  • (Human serum)
  • GTP inhibition
  • Glutamate dehydrogenase
  • Reye's syndrome

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology

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