Glutamate dehydrogenase in Reye's syndrome Evidence for the presence of an altered enzyme in serum with increased susceptibility to inhibition by GTP

Jeffrey T. Holt, Dean A. Arvan, Theodor Mayer, Thomas Smith, J. Ellis Bell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The glutamate dehydrogenase activity found in the serum of patients with Reye's syndrome is shown to be inhibited about 1000-fold more potently by GTP than is the normal human enzyme. 1 mM ADP, which with the normal enzyme effectively reverse GTP inhibition, has no effect in the GTP inhibition of the Reye's syndrome serum activity.

Original languageEnglish (US)
Pages (from-to)42-46
Number of pages5
JournalBiochimica et Biophysica Acta (BBA)/Protein Structure and Molecular
Volume749
Issue number1
DOIs
StatePublished - Nov 28 1983
Externally publishedYes

Fingerprint

Reye Syndrome
Glutamate Dehydrogenase
Guanosine Triphosphate
Enzymes
Serum
Adenosine Diphosphate

Keywords

  • (Human serum)
  • Glutamate dehydrogenase
  • GTP inhibition
  • Reye's syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Structural Biology

Cite this

Glutamate dehydrogenase in Reye's syndrome Evidence for the presence of an altered enzyme in serum with increased susceptibility to inhibition by GTP. / Holt, Jeffrey T.; Arvan, Dean A.; Mayer, Theodor; Smith, Thomas; Bell, J. Ellis.

In: Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, Vol. 749, No. 1, 28.11.1983, p. 42-46.

Research output: Contribution to journalArticle

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