Glutamate dehydrogenase in Reye's syndrome Evidence for the presence of an altered enzyme in serum with increased susceptibility to inhibition by GTP

Jeffrey T. Holt; Dean A. Arvan; Theodor Mayer; Thomas J. Smith; J. Ellis Bell

doi:10.1016/0167-4838(83)90148-6

Glutamate dehydrogenase in Reye's syndrome Evidence for the presence of an altered enzyme in serum with increased susceptibility to inhibition by GTP

Jeffrey T. Holt
, Dean A. Arvan
, Theodor Mayer
, Thomas J. Smith
, J. Ellis Bell

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The glutamate dehydrogenase activity found in the serum of patients with Reye's syndrome is shown to be inhibited about 1000-fold more potently by GTP than is the normal human enzyme. 1 mM ADP, which with the normal enzyme effectively reverse GTP inhibition, has no effect in the GTP inhibition of the Reye's syndrome serum activity.

Original language	English (US)
Pages (from-to)	42-46
Number of pages	5
Journal	Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology
Volume	749
Issue number	1
DOIs	https://doi.org/10.1016/0167-4838(83)90148-6
State	Published - Nov 28 1983
Externally published	Yes

Keywords

(Human serum)
GTP inhibition
Glutamate dehydrogenase
Reye's syndrome

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology

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10.1016/0167-4838(83)90148-6

Cite this

Glutamate dehydrogenase in Reye's syndrome Evidence for the presence of an altered enzyme in serum with increased susceptibility to inhibition by GTP. / Holt, Jeffrey T.; Arvan, Dean A.; Mayer, Theodor et al.
In: Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, Vol. 749, No. 1, 28.11.1983, p. 42-46.

Research output: Contribution to journal › Article › peer-review

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abstract = "The glutamate dehydrogenase activity found in the serum of patients with Reye's syndrome is shown to be inhibited about 1000-fold more potently by GTP than is the normal human enzyme. 1 mM ADP, which with the normal enzyme effectively reverse GTP inhibition, has no effect in the GTP inhibition of the Reye's syndrome serum activity.",

keywords = "(Human serum), GTP inhibition, Glutamate dehydrogenase, Reye's syndrome",

author = "Holt, \{Jeffrey T.\} and Arvan, \{Dean A.\} and Theodor Mayer and Smith, \{Thomas J.\} and Bell, \{J. Ellis\}",

note = "Funding Information: We thank Lisa Linske and Evelyn Bell for expert technical assistance in conducting some of these experiments. This work was supported, in part, by National Institutes of Health Grant No. GM 30195 to J.E.B.",

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AU - Holt, Jeffrey T.

AU - Arvan, Dean A.

AU - Mayer, Theodor

AU - Smith, Thomas J.

AU - Bell, J. Ellis

N1 - Funding Information: We thank Lisa Linske and Evelyn Bell for expert technical assistance in conducting some of these experiments. This work was supported, in part, by National Institutes of Health Grant No. GM 30195 to J.E.B.

PY - 1983/11/28

Y1 - 1983/11/28

N2 - The glutamate dehydrogenase activity found in the serum of patients with Reye's syndrome is shown to be inhibited about 1000-fold more potently by GTP than is the normal human enzyme. 1 mM ADP, which with the normal enzyme effectively reverse GTP inhibition, has no effect in the GTP inhibition of the Reye's syndrome serum activity.

AB - The glutamate dehydrogenase activity found in the serum of patients with Reye's syndrome is shown to be inhibited about 1000-fold more potently by GTP than is the normal human enzyme. 1 mM ADP, which with the normal enzyme effectively reverse GTP inhibition, has no effect in the GTP inhibition of the Reye's syndrome serum activity.

KW - (Human serum)

KW - GTP inhibition

KW - Glutamate dehydrogenase

KW - Reye's syndrome

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IS - 1

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Glutamate dehydrogenase in Reye's syndrome Evidence for the presence of an altered enzyme in serum with increased susceptibility to inhibition by GTP

Abstract

Keywords

ASJC Scopus subject areas

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