Glutamate dehydrogenase: Structure, regulation, and its role in insulin homeostasis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter reviews the structure and allosteric regulation of glutamate dehydrogenase (GDH). For decades, it was known that mammalian GDH was regulated by a wide array of metabolites, but the reason for such regulation was not at all clear. The demonstration that hyperinsulinism/hyperammonemia (HHS) is caused by the loss of some of this regulation, for the first time, demonstrated that GDH regulation was essential for insulin homeostasis. Presented here are the atomic details for this complex network of allosteric regulation and how such information can lead to development of pharmaceutical agents that might not only be useful in treating HHS, but may also have utility as anticancer agents.

Original languageEnglish
Title of host publicationMonogenic Hyperinsulinemic Hypoglycemia Disorders
PublisherS. Karger AG
Pages87-99
Number of pages13
Volume21
ISBN (Print)9783805599443, 9783805599436
DOIs
StatePublished - Feb 16 2012
Externally publishedYes

Fingerprint

Glutamate Dehydrogenase
Allosteric Regulation
Homeostasis
Insulin
Naphazoline
Hyperammonemia
Hyperinsulinism
Complex networks
Metabolites
Antineoplastic Agents
Demonstrations
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Smith, T. (2012). Glutamate dehydrogenase: Structure, regulation, and its role in insulin homeostasis. In Monogenic Hyperinsulinemic Hypoglycemia Disorders (Vol. 21, pp. 87-99). S. Karger AG. https://doi.org/10.1159/000334514

Glutamate dehydrogenase : Structure, regulation, and its role in insulin homeostasis. / Smith, Thomas.

Monogenic Hyperinsulinemic Hypoglycemia Disorders. Vol. 21 S. Karger AG, 2012. p. 87-99.

Research output: Chapter in Book/Report/Conference proceedingChapter

Smith, T 2012, Glutamate dehydrogenase: Structure, regulation, and its role in insulin homeostasis. in Monogenic Hyperinsulinemic Hypoglycemia Disorders. vol. 21, S. Karger AG, pp. 87-99. https://doi.org/10.1159/000334514
Smith T. Glutamate dehydrogenase: Structure, regulation, and its role in insulin homeostasis. In Monogenic Hyperinsulinemic Hypoglycemia Disorders. Vol. 21. S. Karger AG. 2012. p. 87-99 https://doi.org/10.1159/000334514
Smith, Thomas. / Glutamate dehydrogenase : Structure, regulation, and its role in insulin homeostasis. Monogenic Hyperinsulinemic Hypoglycemia Disorders. Vol. 21 S. Karger AG, 2012. pp. 87-99
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