7. Summary: Data from both animals and humans indicate that peripheral glutamate receptors are involved in nociceptive transmission in the normal and inflamed state. Studies in animal models indicate that peripheral glutamate receptors may provide novel targets for treatment of inflammatory pain. The variety of peripheral iGlu and mGlu receptors provides many targets for drug development. Manipulating the peripheral glutamatergic system could lead to advances in treating maladaptive pain while avoiding CNS side effects.
|Original language||English (US)|
|Title of host publication||Glutamate Receptors in Peripheral Tissue|
|Subtitle of host publication||Excitatory Transmission Outside the CNS|
|Number of pages||10|
|ISBN (Print)||0306479737, 9780306479731|
|State||Published - 2005|
ASJC Scopus subject areas