Glutamate receptors and their role in acute and inflammatory pain

Susan M. Carlton

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

7. Summary: Data from both animals and humans indicate that peripheral glutamate receptors are involved in nociceptive transmission in the normal and inflamed state. Studies in animal models indicate that peripheral glutamate receptors may provide novel targets for treatment of inflammatory pain. The variety of peripheral iGlu and mGlu receptors provides many targets for drug development. Manipulating the peripheral glutamatergic system could lead to advances in treating maladaptive pain while avoiding CNS side effects.

Original languageEnglish (US)
Title of host publicationGlutamate Receptors in Peripheral Tissue
Subtitle of host publicationExcitatory Transmission Outside the CNS
PublisherSpringer US
Pages87-96
Number of pages10
ISBN (Electronic)9780306486449
ISBN (Print)0306479737, 9780306479731
DOIs
StatePublished - 2005

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience

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