Glutamine enhances gut glutathione production

Yihong Cao, Zuliang Feng, Annie Hoos, Vicki Klimberg

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Background: The gastrointestinal tract is recognized as having important metabolic functions. This study examined gut glutathione (GSH) extraction and the effect of supplemental oral glutamine (GLN) on gut GSH fractional release. Methods: Healthy female Fisher-344 rats weighing approximately 150 to 200 g were pair-fed chow and supplemented by gavage with 1 g/kg/d GLN or an isonitrogenous amount of Freamine (McGaw, St Louis, MO). Rats were sacrificed at 6 weeks. Arterial and portal blood was assayed for GLN and GSH content. The gut GLN and GSH extractions were calculated. Results: The gut GLN fractional uptake was increased by approximately 50%, and there was a near threefold increase in gut GSH fractional release in the GLN-supplemented group. Conclusions: The discovery of gut's role as a major producer of GSH may give insight into why feeding via the gut rather than by the venous route is so important. Supplemental oral GLN further enhances GLN extraction as well as GSH fractional release in the gut.

Original languageEnglish (US)
Pages (from-to)224-227
Number of pages4
JournalJournal of Parenteral and Enteral Nutrition
Volume22
Issue number4
StatePublished - 1998
Externally publishedYes

Fingerprint

Glutamine
Glutathione
Gastrointestinal Tract

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Glutamine enhances gut glutathione production. / Cao, Yihong; Feng, Zuliang; Hoos, Annie; Klimberg, Vicki.

In: Journal of Parenteral and Enteral Nutrition, Vol. 22, No. 4, 1998, p. 224-227.

Research output: Contribution to journalArticle

Cao, Yihong ; Feng, Zuliang ; Hoos, Annie ; Klimberg, Vicki. / Glutamine enhances gut glutathione production. In: Journal of Parenteral and Enteral Nutrition. 1998 ; Vol. 22, No. 4. pp. 224-227.
@article{83d97b827cc74a7483d2f58ba0b21225,
title = "Glutamine enhances gut glutathione production",
abstract = "Background: The gastrointestinal tract is recognized as having important metabolic functions. This study examined gut glutathione (GSH) extraction and the effect of supplemental oral glutamine (GLN) on gut GSH fractional release. Methods: Healthy female Fisher-344 rats weighing approximately 150 to 200 g were pair-fed chow and supplemented by gavage with 1 g/kg/d GLN or an isonitrogenous amount of Freamine (McGaw, St Louis, MO). Rats were sacrificed at 6 weeks. Arterial and portal blood was assayed for GLN and GSH content. The gut GLN and GSH extractions were calculated. Results: The gut GLN fractional uptake was increased by approximately 50{\%}, and there was a near threefold increase in gut GSH fractional release in the GLN-supplemented group. Conclusions: The discovery of gut's role as a major producer of GSH may give insight into why feeding via the gut rather than by the venous route is so important. Supplemental oral GLN further enhances GLN extraction as well as GSH fractional release in the gut.",
author = "Yihong Cao and Zuliang Feng and Annie Hoos and Vicki Klimberg",
year = "1998",
language = "English (US)",
volume = "22",
pages = "224--227",
journal = "JPEN. Journal of parenteral and enteral nutrition",
issn = "0148-6071",
publisher = "SAGE Publications Inc.",
number = "4",

}

TY - JOUR

T1 - Glutamine enhances gut glutathione production

AU - Cao, Yihong

AU - Feng, Zuliang

AU - Hoos, Annie

AU - Klimberg, Vicki

PY - 1998

Y1 - 1998

N2 - Background: The gastrointestinal tract is recognized as having important metabolic functions. This study examined gut glutathione (GSH) extraction and the effect of supplemental oral glutamine (GLN) on gut GSH fractional release. Methods: Healthy female Fisher-344 rats weighing approximately 150 to 200 g were pair-fed chow and supplemented by gavage with 1 g/kg/d GLN or an isonitrogenous amount of Freamine (McGaw, St Louis, MO). Rats were sacrificed at 6 weeks. Arterial and portal blood was assayed for GLN and GSH content. The gut GLN and GSH extractions were calculated. Results: The gut GLN fractional uptake was increased by approximately 50%, and there was a near threefold increase in gut GSH fractional release in the GLN-supplemented group. Conclusions: The discovery of gut's role as a major producer of GSH may give insight into why feeding via the gut rather than by the venous route is so important. Supplemental oral GLN further enhances GLN extraction as well as GSH fractional release in the gut.

AB - Background: The gastrointestinal tract is recognized as having important metabolic functions. This study examined gut glutathione (GSH) extraction and the effect of supplemental oral glutamine (GLN) on gut GSH fractional release. Methods: Healthy female Fisher-344 rats weighing approximately 150 to 200 g were pair-fed chow and supplemented by gavage with 1 g/kg/d GLN or an isonitrogenous amount of Freamine (McGaw, St Louis, MO). Rats were sacrificed at 6 weeks. Arterial and portal blood was assayed for GLN and GSH content. The gut GLN and GSH extractions were calculated. Results: The gut GLN fractional uptake was increased by approximately 50%, and there was a near threefold increase in gut GSH fractional release in the GLN-supplemented group. Conclusions: The discovery of gut's role as a major producer of GSH may give insight into why feeding via the gut rather than by the venous route is so important. Supplemental oral GLN further enhances GLN extraction as well as GSH fractional release in the gut.

UR - http://www.scopus.com/inward/record.url?scp=0031799552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031799552&partnerID=8YFLogxK

M3 - Article

VL - 22

SP - 224

EP - 227

JO - JPEN. Journal of parenteral and enteral nutrition

JF - JPEN. Journal of parenteral and enteral nutrition

SN - 0148-6071

IS - 4

ER -