Glutathione and tissue amino acid responses to light-exposed parenteral nutrients

Jatinder Bhatia, Mary T. Moslen, Lata Kaphalia, David K. Rassin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Effects of infusion of light-exposed (+L) or light-protected (-L) total parenteral nutrition solutions were investigated in rats. The parenteral infusions were carried out for 7 days through jugular cannulas in freely moving rats in metabolic cages. Plasma tyrosine and citrulline, hepatic methionine, valine, isoleucine, leucine and tyrosine, and biliary cystathionine were significantly greater in the -L than +L rats, whereas biliary arginine was significantly lower in the -L compared to +L rats. Bile flow, biliary inorganic phosphate and glucose were significantly lower, whereas biliary total glutathione (GSH+GSSG) was significantly greater in the - L compared to +L animals. These data suggest adverse effects on hepatobiliary function due to light exposure of parenteral nutrients. The endogenous markers used suggest that tight junction permeability, bile acid-independent flow, glutathione and amino acid homeostasis are altered by light exposure and that these changes can be minimized by light protection. The mechanisms involved in the induction of these changes need to be elucidated. The role of light exposure of parenteral nutrients during routine clinical use in the induction of hepatic dysfunction, a common metabolic complication of parenteral nutrition, needs to be considered.

Original languageEnglish (US)
Pages (from-to)79-89
Number of pages11
JournalToxicology Letters
Volume63
Issue number1
DOIs
StatePublished - 1992

Fingerprint

Nutrients
Glutathione
Tissue
Light
Amino Acids
Food
Rats
Tyrosine
Parenteral Nutrition Solutions
Cystathionine
Parenteral Infusions
Citrulline
Glutathione Disulfide
Total Parenteral Nutrition
Isoleucine
Tight Junctions
Liver
Parenteral Nutrition
Valine
Nutrition

Keywords

  • Amino acids
  • Glutathione
  • Light

ASJC Scopus subject areas

  • Toxicology

Cite this

Glutathione and tissue amino acid responses to light-exposed parenteral nutrients. / Bhatia, Jatinder; Moslen, Mary T.; Kaphalia, Lata; Rassin, David K.

In: Toxicology Letters, Vol. 63, No. 1, 1992, p. 79-89.

Research output: Contribution to journalArticle

Bhatia, Jatinder ; Moslen, Mary T. ; Kaphalia, Lata ; Rassin, David K. / Glutathione and tissue amino acid responses to light-exposed parenteral nutrients. In: Toxicology Letters. 1992 ; Vol. 63, No. 1. pp. 79-89.
@article{010acc35adc5420da6bb867ff7e4a44d,
title = "Glutathione and tissue amino acid responses to light-exposed parenteral nutrients",
abstract = "Effects of infusion of light-exposed (+L) or light-protected (-L) total parenteral nutrition solutions were investigated in rats. The parenteral infusions were carried out for 7 days through jugular cannulas in freely moving rats in metabolic cages. Plasma tyrosine and citrulline, hepatic methionine, valine, isoleucine, leucine and tyrosine, and biliary cystathionine were significantly greater in the -L than +L rats, whereas biliary arginine was significantly lower in the -L compared to +L rats. Bile flow, biliary inorganic phosphate and glucose were significantly lower, whereas biliary total glutathione (GSH+GSSG) was significantly greater in the - L compared to +L animals. These data suggest adverse effects on hepatobiliary function due to light exposure of parenteral nutrients. The endogenous markers used suggest that tight junction permeability, bile acid-independent flow, glutathione and amino acid homeostasis are altered by light exposure and that these changes can be minimized by light protection. The mechanisms involved in the induction of these changes need to be elucidated. The role of light exposure of parenteral nutrients during routine clinical use in the induction of hepatic dysfunction, a common metabolic complication of parenteral nutrition, needs to be considered.",
keywords = "Amino acids, Glutathione, Light",
author = "Jatinder Bhatia and Moslen, {Mary T.} and Lata Kaphalia and Rassin, {David K.}",
year = "1992",
doi = "10.1016/0378-4274(92)90110-6",
language = "English (US)",
volume = "63",
pages = "79--89",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Glutathione and tissue amino acid responses to light-exposed parenteral nutrients

AU - Bhatia, Jatinder

AU - Moslen, Mary T.

AU - Kaphalia, Lata

AU - Rassin, David K.

PY - 1992

Y1 - 1992

N2 - Effects of infusion of light-exposed (+L) or light-protected (-L) total parenteral nutrition solutions were investigated in rats. The parenteral infusions were carried out for 7 days through jugular cannulas in freely moving rats in metabolic cages. Plasma tyrosine and citrulline, hepatic methionine, valine, isoleucine, leucine and tyrosine, and biliary cystathionine were significantly greater in the -L than +L rats, whereas biliary arginine was significantly lower in the -L compared to +L rats. Bile flow, biliary inorganic phosphate and glucose were significantly lower, whereas biliary total glutathione (GSH+GSSG) was significantly greater in the - L compared to +L animals. These data suggest adverse effects on hepatobiliary function due to light exposure of parenteral nutrients. The endogenous markers used suggest that tight junction permeability, bile acid-independent flow, glutathione and amino acid homeostasis are altered by light exposure and that these changes can be minimized by light protection. The mechanisms involved in the induction of these changes need to be elucidated. The role of light exposure of parenteral nutrients during routine clinical use in the induction of hepatic dysfunction, a common metabolic complication of parenteral nutrition, needs to be considered.

AB - Effects of infusion of light-exposed (+L) or light-protected (-L) total parenteral nutrition solutions were investigated in rats. The parenteral infusions were carried out for 7 days through jugular cannulas in freely moving rats in metabolic cages. Plasma tyrosine and citrulline, hepatic methionine, valine, isoleucine, leucine and tyrosine, and biliary cystathionine were significantly greater in the -L than +L rats, whereas biliary arginine was significantly lower in the -L compared to +L rats. Bile flow, biliary inorganic phosphate and glucose were significantly lower, whereas biliary total glutathione (GSH+GSSG) was significantly greater in the - L compared to +L animals. These data suggest adverse effects on hepatobiliary function due to light exposure of parenteral nutrients. The endogenous markers used suggest that tight junction permeability, bile acid-independent flow, glutathione and amino acid homeostasis are altered by light exposure and that these changes can be minimized by light protection. The mechanisms involved in the induction of these changes need to be elucidated. The role of light exposure of parenteral nutrients during routine clinical use in the induction of hepatic dysfunction, a common metabolic complication of parenteral nutrition, needs to be considered.

KW - Amino acids

KW - Glutathione

KW - Light

UR - http://www.scopus.com/inward/record.url?scp=0026660537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026660537&partnerID=8YFLogxK

U2 - 10.1016/0378-4274(92)90110-6

DO - 10.1016/0378-4274(92)90110-6

M3 - Article

VL - 63

SP - 79

EP - 89

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - 1

ER -