Glycolipid and mucopolysaccharide abnormality in fibroblasts of Fabry's disease

Reuben Matalon; Albert Dorfman; Glyn Dawson; Charles C. Sweeley

doi:10.1126/science.164.3887.1522

Glycolipid and mucopolysaccharide abnormality in fibroblasts of Fabry's disease

Reuben Matalon, Albert Dorfman, Glyn Dawson, Charles C. Sweeley

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Cultures of skin fiibroblasts from a patient with Fabry's disease showed an accumulation of the glycolipid, galactosyl-galactosyl-glucosyl ceramide. Such cells also showed metachromasia on staining with toluidine blue and a markedly elevated acid mucopolysaccharide content.

Original language	English (US)
Pages (from-to)	1522-1523
Number of pages	2
Journal	Science
Volume	164
Issue number	3887
DOIs	https://doi.org/10.1126/science.164.3887.1522
State	Published - Jan 1 1969
Externally published	Yes

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title = "Glycolipid and mucopolysaccharide abnormality in fibroblasts of Fabry's disease",

abstract = "Cultures of skin fiibroblasts from a patient with Fabry's disease showed an accumulation of the glycolipid, galactosyl-galactosyl-glucosyl ceramide. Such cells also showed metachromasia on staining with toluidine blue and a markedly elevated acid mucopolysaccharide content.",

author = "Reuben Matalon and Albert Dorfman and Glyn Dawson and Sweeley, {Charles C.}",

year = "1969",

month = jan,

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doi = "10.1126/science.164.3887.1522",

language = "English (US)",

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pages = "1522--1523",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - Glycolipid and mucopolysaccharide abnormality in fibroblasts of Fabry's disease

AU - Matalon, Reuben

AU - Dorfman, Albert

AU - Dawson, Glyn

AU - Sweeley, Charles C.

PY - 1969/1/1

Y1 - 1969/1/1

N2 - Cultures of skin fiibroblasts from a patient with Fabry's disease showed an accumulation of the glycolipid, galactosyl-galactosyl-glucosyl ceramide. Such cells also showed metachromasia on staining with toluidine blue and a markedly elevated acid mucopolysaccharide content.

AB - Cultures of skin fiibroblasts from a patient with Fabry's disease showed an accumulation of the glycolipid, galactosyl-galactosyl-glucosyl ceramide. Such cells also showed metachromasia on staining with toluidine blue and a markedly elevated acid mucopolysaccharide content.

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