Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated listeria monocytogenes

Kelly Olino, Barish H. Edil, Kristen F. Meckel, Xiaoyu Pan, Avesh Thuluvath, Drew M. Pardoll, Richard D. Schulick, Kiyoshi Yoshimura, Walter P. Weber

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Previous work demonstrated that a subset of natural killer T cells in mice decreased the antitumor efficacy of live attenuated Listeria monocytogenes where the actin A and internalin B genes were genetically deleted (LMD) against murine hepatic colorectal cancer metastases. Therefore, we hypothesized that the use of specific glycolipids known to selectively stimulate natural killer T-cell subsets used alone or co-administered with LMD would increase survival. We found that early or multiple administrations of glycolipids after tumor challenge had a strong impact on survival with or without LMD. Solitary administration or treatment given later was less efficacious but still showed a strong trend toward enhancing the antitumor activity of LMD. These results underscore the potential of glycolipids in the treatment of hepatic metastases and encourage further investigations into the immunomodulation of natural killer T cells to enhance the antitumor activity of LMD.

Original languageEnglish (US)
Pages (from-to)480-482
Number of pages3
JournalArchives of Surgery
Volume147
Issue number5
DOIs
StatePublished - May 2012
Externally publishedYes

Fingerprint

Natural Killer T-Cells
Glycolipids
Listeria monocytogenes
Therapeutic Uses
Liver Neoplasms
Colorectal Neoplasms
Neoplasm Metastasis
Antigens
Immunomodulation
T-Lymphocyte Subsets
Actins
Liver
Therapeutics
Genes
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated listeria monocytogenes. / Olino, Kelly; Edil, Barish H.; Meckel, Kristen F.; Pan, Xiaoyu; Thuluvath, Avesh; Pardoll, Drew M.; Schulick, Richard D.; Yoshimura, Kiyoshi; Weber, Walter P.

In: Archives of Surgery, Vol. 147, No. 5, 05.2012, p. 480-482.

Research output: Contribution to journalArticle

Olino, K, Edil, BH, Meckel, KF, Pan, X, Thuluvath, A, Pardoll, DM, Schulick, RD, Yoshimura, K & Weber, WP 2012, 'Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated listeria monocytogenes', Archives of Surgery, vol. 147, no. 5, pp. 480-482. https://doi.org/10.1001/archsurg.2011.2206
Olino, Kelly ; Edil, Barish H. ; Meckel, Kristen F. ; Pan, Xiaoyu ; Thuluvath, Avesh ; Pardoll, Drew M. ; Schulick, Richard D. ; Yoshimura, Kiyoshi ; Weber, Walter P. / Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated listeria monocytogenes. In: Archives of Surgery. 2012 ; Vol. 147, No. 5. pp. 480-482.
@article{58f8799e053f45f3a1523d815367de5e,
title = "Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated listeria monocytogenes",
abstract = "Previous work demonstrated that a subset of natural killer T cells in mice decreased the antitumor efficacy of live attenuated Listeria monocytogenes where the actin A and internalin B genes were genetically deleted (LMD) against murine hepatic colorectal cancer metastases. Therefore, we hypothesized that the use of specific glycolipids known to selectively stimulate natural killer T-cell subsets used alone or co-administered with LMD would increase survival. We found that early or multiple administrations of glycolipids after tumor challenge had a strong impact on survival with or without LMD. Solitary administration or treatment given later was less efficacious but still showed a strong trend toward enhancing the antitumor activity of LMD. These results underscore the potential of glycolipids in the treatment of hepatic metastases and encourage further investigations into the immunomodulation of natural killer T cells to enhance the antitumor activity of LMD.",
author = "Kelly Olino and Edil, {Barish H.} and Meckel, {Kristen F.} and Xiaoyu Pan and Avesh Thuluvath and Pardoll, {Drew M.} and Schulick, {Richard D.} and Kiyoshi Yoshimura and Weber, {Walter P.}",
year = "2012",
month = "5",
doi = "10.1001/archsurg.2011.2206",
language = "English (US)",
volume = "147",
pages = "480--482",
journal = "JAMA Surgery",
issn = "2168-6254",
publisher = "American Medical Association",
number = "5",

}

TY - JOUR

T1 - Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated listeria monocytogenes

AU - Olino, Kelly

AU - Edil, Barish H.

AU - Meckel, Kristen F.

AU - Pan, Xiaoyu

AU - Thuluvath, Avesh

AU - Pardoll, Drew M.

AU - Schulick, Richard D.

AU - Yoshimura, Kiyoshi

AU - Weber, Walter P.

PY - 2012/5

Y1 - 2012/5

N2 - Previous work demonstrated that a subset of natural killer T cells in mice decreased the antitumor efficacy of live attenuated Listeria monocytogenes where the actin A and internalin B genes were genetically deleted (LMD) against murine hepatic colorectal cancer metastases. Therefore, we hypothesized that the use of specific glycolipids known to selectively stimulate natural killer T-cell subsets used alone or co-administered with LMD would increase survival. We found that early or multiple administrations of glycolipids after tumor challenge had a strong impact on survival with or without LMD. Solitary administration or treatment given later was less efficacious but still showed a strong trend toward enhancing the antitumor activity of LMD. These results underscore the potential of glycolipids in the treatment of hepatic metastases and encourage further investigations into the immunomodulation of natural killer T cells to enhance the antitumor activity of LMD.

AB - Previous work demonstrated that a subset of natural killer T cells in mice decreased the antitumor efficacy of live attenuated Listeria monocytogenes where the actin A and internalin B genes were genetically deleted (LMD) against murine hepatic colorectal cancer metastases. Therefore, we hypothesized that the use of specific glycolipids known to selectively stimulate natural killer T-cell subsets used alone or co-administered with LMD would increase survival. We found that early or multiple administrations of glycolipids after tumor challenge had a strong impact on survival with or without LMD. Solitary administration or treatment given later was less efficacious but still showed a strong trend toward enhancing the antitumor activity of LMD. These results underscore the potential of glycolipids in the treatment of hepatic metastases and encourage further investigations into the immunomodulation of natural killer T cells to enhance the antitumor activity of LMD.

UR - http://www.scopus.com/inward/record.url?scp=84861390548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861390548&partnerID=8YFLogxK

U2 - 10.1001/archsurg.2011.2206

DO - 10.1001/archsurg.2011.2206

M3 - Article

C2 - 22785644

AN - SCOPUS:84861390548

VL - 147

SP - 480

EP - 482

JO - JAMA Surgery

JF - JAMA Surgery

SN - 2168-6254

IS - 5

ER -