Glycyrrhizin improves the resistance of MAIDS mice to opportunistic infection of Candida albicans through the modulation of MAIDS-associated type 2 T cell responses

Tokuichiro Utsunomiya, Makiko Kobayashi, Masahiko Ito, Richard B. Pollard, Fujio Suzuki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Compared with normal mice, MAIDS mice (mice infected with LP-BM5 murine leukemia virus) exhibited an increase up to 100 times greater in susceptibility to infection with Candida albicans. The impaired resistance of MAIDS mice to the infection was recovered to levels observed in normal mice by the administration of glycyrrhizin (GR), an active component of licorice roots. MAIDS mice inoculated with CD4+ T cells from GR-treated mice were also resistant to C. albicans infection. Normal mice inoculated with CD4+ T helper type 2 cells (Th2 cells) from MAIDS mice were susceptible to C. albicans infection at the same levels shown in MAIDS mice. The susceptibility of normal mice inoculated with type 2 T cells was reversible by (i) administration of GR and (ii) inoculation of CD4+ T cells from GR-treated mice and injection of a mixture of mAbs targeted against type 2 cytokines (IL-4 and IL-10). Type 2 cytokines were not detected in sera of MAIDS mice inoculated with CD4+ T cells from GR-treated mice, while they were present in sera of MAIDS mice treated with saline. These results suggest that, by inducing CD4+ T cells which suppress type 2 cytokine production by MAIDS- associated Th2 cells, GR improves the resistance of MAIDS mice to C. albicans infection. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)145-155
Number of pages11
JournalClinical Immunology
Volume95
Issue number2
DOIs
StatePublished - May 2000

Fingerprint

Murine Acquired Immunodeficiency Syndrome
Glycyrrhizic Acid
Opportunistic Infections
Candida albicans
T-Lymphocytes
Infection
Th2 Cells
Cytokines
Glycyrrhiza

Keywords

  • Candida albicans
  • Glycyrrhizin
  • MAIDS
  • Type 2 T cell responses

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Glycyrrhizin improves the resistance of MAIDS mice to opportunistic infection of Candida albicans through the modulation of MAIDS-associated type 2 T cell responses. / Utsunomiya, Tokuichiro; Kobayashi, Makiko; Ito, Masahiko; Pollard, Richard B.; Suzuki, Fujio.

In: Clinical Immunology, Vol. 95, No. 2, 05.2000, p. 145-155.

Research output: Contribution to journalArticle

@article{ee4cd44f8740455f8c9abec874ef0cb2,
title = "Glycyrrhizin improves the resistance of MAIDS mice to opportunistic infection of Candida albicans through the modulation of MAIDS-associated type 2 T cell responses",
abstract = "Compared with normal mice, MAIDS mice (mice infected with LP-BM5 murine leukemia virus) exhibited an increase up to 100 times greater in susceptibility to infection with Candida albicans. The impaired resistance of MAIDS mice to the infection was recovered to levels observed in normal mice by the administration of glycyrrhizin (GR), an active component of licorice roots. MAIDS mice inoculated with CD4+ T cells from GR-treated mice were also resistant to C. albicans infection. Normal mice inoculated with CD4+ T helper type 2 cells (Th2 cells) from MAIDS mice were susceptible to C. albicans infection at the same levels shown in MAIDS mice. The susceptibility of normal mice inoculated with type 2 T cells was reversible by (i) administration of GR and (ii) inoculation of CD4+ T cells from GR-treated mice and injection of a mixture of mAbs targeted against type 2 cytokines (IL-4 and IL-10). Type 2 cytokines were not detected in sera of MAIDS mice inoculated with CD4+ T cells from GR-treated mice, while they were present in sera of MAIDS mice treated with saline. These results suggest that, by inducing CD4+ T cells which suppress type 2 cytokine production by MAIDS- associated Th2 cells, GR improves the resistance of MAIDS mice to C. albicans infection. (C) 2000 Academic Press.",
keywords = "Candida albicans, Glycyrrhizin, MAIDS, Type 2 T cell responses",
author = "Tokuichiro Utsunomiya and Makiko Kobayashi and Masahiko Ito and Pollard, {Richard B.} and Fujio Suzuki",
year = "2000",
month = "5",
doi = "10.1006/clim.2000.4854",
language = "English (US)",
volume = "95",
pages = "145--155",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Glycyrrhizin improves the resistance of MAIDS mice to opportunistic infection of Candida albicans through the modulation of MAIDS-associated type 2 T cell responses

AU - Utsunomiya, Tokuichiro

AU - Kobayashi, Makiko

AU - Ito, Masahiko

AU - Pollard, Richard B.

AU - Suzuki, Fujio

PY - 2000/5

Y1 - 2000/5

N2 - Compared with normal mice, MAIDS mice (mice infected with LP-BM5 murine leukemia virus) exhibited an increase up to 100 times greater in susceptibility to infection with Candida albicans. The impaired resistance of MAIDS mice to the infection was recovered to levels observed in normal mice by the administration of glycyrrhizin (GR), an active component of licorice roots. MAIDS mice inoculated with CD4+ T cells from GR-treated mice were also resistant to C. albicans infection. Normal mice inoculated with CD4+ T helper type 2 cells (Th2 cells) from MAIDS mice were susceptible to C. albicans infection at the same levels shown in MAIDS mice. The susceptibility of normal mice inoculated with type 2 T cells was reversible by (i) administration of GR and (ii) inoculation of CD4+ T cells from GR-treated mice and injection of a mixture of mAbs targeted against type 2 cytokines (IL-4 and IL-10). Type 2 cytokines were not detected in sera of MAIDS mice inoculated with CD4+ T cells from GR-treated mice, while they were present in sera of MAIDS mice treated with saline. These results suggest that, by inducing CD4+ T cells which suppress type 2 cytokine production by MAIDS- associated Th2 cells, GR improves the resistance of MAIDS mice to C. albicans infection. (C) 2000 Academic Press.

AB - Compared with normal mice, MAIDS mice (mice infected with LP-BM5 murine leukemia virus) exhibited an increase up to 100 times greater in susceptibility to infection with Candida albicans. The impaired resistance of MAIDS mice to the infection was recovered to levels observed in normal mice by the administration of glycyrrhizin (GR), an active component of licorice roots. MAIDS mice inoculated with CD4+ T cells from GR-treated mice were also resistant to C. albicans infection. Normal mice inoculated with CD4+ T helper type 2 cells (Th2 cells) from MAIDS mice were susceptible to C. albicans infection at the same levels shown in MAIDS mice. The susceptibility of normal mice inoculated with type 2 T cells was reversible by (i) administration of GR and (ii) inoculation of CD4+ T cells from GR-treated mice and injection of a mixture of mAbs targeted against type 2 cytokines (IL-4 and IL-10). Type 2 cytokines were not detected in sera of MAIDS mice inoculated with CD4+ T cells from GR-treated mice, while they were present in sera of MAIDS mice treated with saline. These results suggest that, by inducing CD4+ T cells which suppress type 2 cytokine production by MAIDS- associated Th2 cells, GR improves the resistance of MAIDS mice to C. albicans infection. (C) 2000 Academic Press.

KW - Candida albicans

KW - Glycyrrhizin

KW - MAIDS

KW - Type 2 T cell responses

UR - http://www.scopus.com/inward/record.url?scp=0034029605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034029605&partnerID=8YFLogxK

U2 - 10.1006/clim.2000.4854

DO - 10.1006/clim.2000.4854

M3 - Article

C2 - 10779408

AN - SCOPUS:0034029605

VL - 95

SP - 145

EP - 155

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 2

ER -