Gold nanoparticles and their applications in biomedicine

Alice F. Versiani, Lídia M. Andrade, Estefânia M.N. Martins, Sérgio Scalzo, Jony M. Geraldo, Claudilene R. Chaves, Daniele C. Ferreira, Marina Ladeira, Silvia Guatimosim, Luiz O. Ladeira, Flávio G. Da Fonseca

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Although used in medical applications for centuries, the development of nanotechnology has shed new light in the plethora of possible medical and biological applications using gold-based nanostructures. Gold nanostructures are stable and relatively inert in biological systems, leading to low reatogenicity, biocompatibility and general lack of toxicity. Allied to that, gold nanoparticles present optical and electronic properties that have been exploited in a range of biomedical applications. In this review we discuss biologically relevant properties of gold nanoparticles and how they are used in some biomedicine fields, especially those involving biosensing of biological analytes-including viruses and antibodies against them, cancer therapies, and antigen delivery, including viral antigens-as part of nonclassic vaccine strategies.

Original languageEnglish (US)
Pages (from-to)293-309
Number of pages17
JournalFuture Virology
Volume11
Issue number4
DOIs
StatePublished - Apr 2016
Externally publishedYes

Keywords

  • biosensor
  • cancer therapy
  • functionalization
  • gold nanoparticles
  • gold nanorods
  • vaccine

ASJC Scopus subject areas

  • Virology

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