Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa

Saam Motamedi; Tuya Shilagard; Kert Edward; Luke Koong; Suimin Qui; Gracie Vargas

doi:10.1364/BOE.2.001194

Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa

Saam Motamedi, Tuya Shilagard, Kert Edward, Luke Koong, Suimin Qui, Gracie Vargas

Neuroscience & Cell

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We explore the feasibility of using gold nanorods with efficient two-photon luminescence properties as contrast agents for intravital imaging of neoplasia. This investigation spanned ex vivo characterization in cells/tissue to in vivo implementation in an oral carcinogenesis model. GNRs were >40 times brighter than surrounding tissue. Intravital imaging revealed 3D microvasculature, and in dysplasia, abnormal vessels (dense and tortuous) compared to normal. GNRs were diffusely distributed in lesions after 24 hours. No known previous study has revealed abnormal vessel structure in dysplasia by imaging. Results suggest GNRs can function as high-contrast agents for in vivo visualization of carcinogenesis features.

Original language	English (US)
Pages (from-to)	1194-1203
Number of pages	10
Journal	Biomedical Optics Express
Volume	2
Issue number	5
DOIs	https://doi.org/10.1364/BOE.2.001194
State	Published - May 1 2011

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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AU - Vargas, Gracie

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Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa

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