Gout as a complication of Bartter's syndrome. A possible role for alkalosis in the decreased clearance of uric acid

Walter Meyer, J. R. Gill, F. C. Bartter

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Abstract

A prevalence of hyperuricemia of 50% and of acute gouty arthritis of 20% has been observed in a group of patients with Bartter's syndrome. All patients except one presented initially with complaints unrelated to uric acid metabolism. The cause of their hyperuricemia and subnormal clearance of uric acid is unexplained. Systemic alkalosis, a prominent feature of Bartter's syndrome, can decrease the clearance of uric acid and may contribute to the hyperuricemia and gout that have been observed. Physicians should be aware of the possibility of gout as a clinical complication of Bartter's syndrome and of the inhibitory effects of alkalosis on urate clearance.

Original languageEnglish (US)
Pages (from-to)56-59
Number of pages4
JournalAnnals of Internal Medicine
Volume83
Issue number1
StatePublished - 1975
Externally publishedYes

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Bartter Syndrome
Alkalosis
Gout
Uric Acid
Hyperuricemia
Gouty Arthritis
Physicians

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gout as a complication of Bartter's syndrome. A possible role for alkalosis in the decreased clearance of uric acid. / Meyer, Walter; Gill, J. R.; Bartter, F. C.

In: Annals of Internal Medicine, Vol. 83, No. 1, 1975, p. 56-59.

Research output: Contribution to journalArticle

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