Graft-versus-host disease: Gastrointestinal involvement with a rectovaginal fistula

Bradley H. Kessler, William J. Cochran, Milton L. Wagner, Hal K. Hawkins, William J. Klish

Research output: Contribution to journalArticle

Abstract

Bone marrow transplantation is an accepted form of treatment for aplastic anemia and end-stage hematological malignancies. Despite a satisfactory outcome in selected patients, more than one-half develop acute graft-versus-host disease (GVHD), characterized typically by involvement of the skin, liver, and gastrointestinal tract. We describe an unusual case in which a 10year-old girl developed gastrointestinal symptoms as the only manifestation of GVHD. The patient presented with a rectovaginal fistula and had clinical, radiological, and histological features of gastrointestinal GVHD without evidence of liver or skin involvement.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume7
Issue number2
DOIs
StatePublished - Mar 1988

Keywords

  • Aplastic anemia
  • Gastrointestinal graft-versus-host disease
  • Gastrointestinal involvement
  • Graft-versus-host disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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