Gram negative wound infection in hospitalised adult burn patients-systematic review and metanalysis-

Ernest A. Azzopardi, Elayne Azzopardi, Liberato Camilleri, Jorge Villapalos, Dean E. Boyce, Peter Dziewulski, William A. Dickson, Iain S. Whitaker

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Background: Gram negative infection is a major determinant of morbidity and survival. Traditional teaching suggests that burn wound infections in different centres are caused by differing sets of causative organisms. This study established whether Gram-negative burn wound isolates associated to clinical wound infection differ between burn centres. Methods: Studies investigating adult hospitalised patients (2000-2010) were critically appraised and qualified to a levels of evidence hierarchy. The contribution of bacterial pathogen type, and burn centre to the variance in standardised incidence of Gram-negative burn wound infection was analysed using two-way analysis of variance. Primary Findings: Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumanni, Enterobacter spp., Proteus spp. and Escherichia coli emerged as the commonest Gram-negative burn wound pathogens. Individual pathogens' incidence did not differ significantly between burn centres (F (4, 20) = 1.1, p = 0.3797; r2 = 9.84). Interpretation: Gram-negative infections predominate in burn surgery. This study is the first to establish that burn wound infections do not differ significantly between burn centres. It is the first study to report the pathogens responsible for the majority of Gram-negative infections in these patients. Whilst burn wound infection is not exclusive to these bacteria, it is hoped that reporting the presence of this group of common Gram-negative "target organisms" facilitate clinical practice and target research towards a defined clinical demand. Copyright:

Original languageEnglish (US)
Article numbere95042
JournalPloS one
Volume9
Issue number4
DOIs
StatePublished - Apr 21 2014
Externally publishedYes

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systematic review
Pathogens
Wound Infection
Burn Units
infection
Infection
pathogens
Analysis of variance (ANOVA)
Enterobacter
Proteus
Acinetobacter
Surgery
Escherichia coli
Incidence
Wounds and Injuries
Klebsiella pneumoniae
Bacteria
Teaching
Pseudomonas aeruginosa
Acinetobacter baumannii

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Azzopardi, E. A., Azzopardi, E., Camilleri, L., Villapalos, J., Boyce, D. E., Dziewulski, P., ... Whitaker, I. S. (2014). Gram negative wound infection in hospitalised adult burn patients-systematic review and metanalysis-. PloS one, 9(4), [e95042]. https://doi.org/10.1371/journal.pone.0095042

Gram negative wound infection in hospitalised adult burn patients-systematic review and metanalysis-. / Azzopardi, Ernest A.; Azzopardi, Elayne; Camilleri, Liberato; Villapalos, Jorge; Boyce, Dean E.; Dziewulski, Peter; Dickson, William A.; Whitaker, Iain S.

In: PloS one, Vol. 9, No. 4, e95042, 21.04.2014.

Research output: Contribution to journalArticle

Azzopardi, EA, Azzopardi, E, Camilleri, L, Villapalos, J, Boyce, DE, Dziewulski, P, Dickson, WA & Whitaker, IS 2014, 'Gram negative wound infection in hospitalised adult burn patients-systematic review and metanalysis-', PloS one, vol. 9, no. 4, e95042. https://doi.org/10.1371/journal.pone.0095042
Azzopardi, Ernest A. ; Azzopardi, Elayne ; Camilleri, Liberato ; Villapalos, Jorge ; Boyce, Dean E. ; Dziewulski, Peter ; Dickson, William A. ; Whitaker, Iain S. / Gram negative wound infection in hospitalised adult burn patients-systematic review and metanalysis-. In: PloS one. 2014 ; Vol. 9, No. 4.
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