Granulocyte-macrophage colony-stimulating factor as a cause of paraneoplastic leukaemoid reaction in advanced transitional cell carcinoma

M. Wetzler, Z. Estrov, M. Talpaz, Avi Markowitz, J. U. Gutterman, R. Kurzrock

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    Increasing evidence suggests that paraneoplastic syndromes may be mediated by tumour-related cytokine release, although the specific factor(s) involved remain poorly defined. Colony-stimulating factors (CSF) and interleukins (IL) promote colony growth in semi-solid media and, when administered in recombinant form, increase blood counts in patients. However, normal serum CSF levels in individuals with physiologic blood counts and the relationship between specific serum CSE levels and paraneoplastic leukaemoid reaction are not well established. In this study, we found that normal serum levels of granulocyte-macrophage CSF (GM-CSF), as measured by ELISA, were generally < 55 pg ml-1; IL-3, < 30 pg ml-1; and granulocyte CSF (G-CSF), < 50 pg ml-1. In contrast, high levels of GM-CSF (132 pg ml-1), but not G-CSF or IL-3, were found in a patient with a transitional cell carcinoma of the renal pelvis and increased leukocytosis correlating with the tumour burden. The GM-CSF was biologically active, as demonstrated by its ability to stimulate colony growth in vitro. Based on these results it appears that autonomous production of GM-CSF is one possible pathophysiologic mechanism underlying leukaemoid reaction in cancer patients.

    Original languageEnglish (US)
    Pages (from-to)417-420
    Number of pages4
    JournalJournal of Internal Medicine
    Volume234
    Issue number4
    StatePublished - 1993

    Fingerprint

    Transitional Cell Carcinoma
    Granulocyte-Macrophage Colony-Stimulating Factor
    Granulocytes
    Colony-Stimulating Factors
    Interleukin-3
    Macrophages
    Serum
    Paraneoplastic Syndromes
    Kidney Pelvis
    Interleukins
    Leukocytosis
    Granulocyte Colony-Stimulating Factor
    Growth
    Tumor Burden
    Neoplasms
    Enzyme-Linked Immunosorbent Assay
    Cytokines

    Keywords

    • G-CSF
    • GM-CSF
    • IL-3
    • leukaemoid
    • transitional cell carcinoma

    ASJC Scopus subject areas

    • Internal Medicine

    Cite this

    Wetzler, M., Estrov, Z., Talpaz, M., Markowitz, A., Gutterman, J. U., & Kurzrock, R. (1993). Granulocyte-macrophage colony-stimulating factor as a cause of paraneoplastic leukaemoid reaction in advanced transitional cell carcinoma. Journal of Internal Medicine, 234(4), 417-420.

    Granulocyte-macrophage colony-stimulating factor as a cause of paraneoplastic leukaemoid reaction in advanced transitional cell carcinoma. / Wetzler, M.; Estrov, Z.; Talpaz, M.; Markowitz, Avi; Gutterman, J. U.; Kurzrock, R.

    In: Journal of Internal Medicine, Vol. 234, No. 4, 1993, p. 417-420.

    Research output: Contribution to journalArticle

    Wetzler, M, Estrov, Z, Talpaz, M, Markowitz, A, Gutterman, JU & Kurzrock, R 1993, 'Granulocyte-macrophage colony-stimulating factor as a cause of paraneoplastic leukaemoid reaction in advanced transitional cell carcinoma', Journal of Internal Medicine, vol. 234, no. 4, pp. 417-420.
    Wetzler, M. ; Estrov, Z. ; Talpaz, M. ; Markowitz, Avi ; Gutterman, J. U. ; Kurzrock, R. / Granulocyte-macrophage colony-stimulating factor as a cause of paraneoplastic leukaemoid reaction in advanced transitional cell carcinoma. In: Journal of Internal Medicine. 1993 ; Vol. 234, No. 4. pp. 417-420.
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