Granulocytic sarcoma involving the uterus and right fallopian tube with negative endometrial biopsy

G. Kilic, U. C. Boruban, C. Bueco-Ramos, S. N. Konoplev

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Granulocytic sarcoma is an extramedullary tumor associated with acute myelogenous leukemia (AML) and it is rarely seen in the female genital tract. We report an unusual case of granulocytic sarcoma of the uterus and fallopian tube in an AML patient who presented with vaginal bleeding and persistent abdominal pain. She was under chemotherapy. Biopsy did not reveal the diagnosis. After laparoscopic examination, hysterectomy with bilateral salpingo-oophorectomy was performed. Pathology showed atypical myeloid cells infiltrating the muscle bundles which was consistent with granulocytic sarcoma involving the uterus and right fallopian tube. Immunohistochemistry confirmed the diagnosis. The patient is in complete remission for AML and being followed-up for granulocytic sarcoma. Granulocytic sarcoma of the uterus and fallopian tube is very rare, and in AML patients with abnormal uterine bleeding but negative endometrial biopsy it should still be considered in the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)270-272
Number of pages3
JournalEuropean Journal of Gynaecological Oncology
Volume28
Issue number4
StatePublished - Aug 15 2007
Externally publishedYes

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Keywords

  • Abnormal uterine bleeding
  • Acute Myeloid Leukemia
  • Fallopian tube
  • Granulocytic Sarcoma
  • Uterus

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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