Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea

Marie Kubota; Mirko Scheibinger; Taha A. Jan; Stefan Heller

doi:10.1016/j.celrep.2020.108646

Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea

Marie Kubota
, Mirko Scheibinger
, Taha A. Jan
, Stefan Heller

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Kubota et al. compare the organoid-formation potential of cochlear cell types and show that greater epithelial ridge cells, adjacent to the neonatal organ of Corti, have the strongest potential. Single-cell transcriptomic analysis confirms the identities of all cochlear cell groups. Their findings advance cell-based assays for development of inner ear therapies.

Original language	English (US)
Article number	108646
Journal	Cell Reports
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2020.108646
State	Published - Jan 19 2021
Externally published	Yes

Keywords

auditory periphery
epigenetic reprogramming
hair cell regeneration
inner ear organoid
otic
supporting cell

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108646

Cite this

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abstract = "Kubota et al. compare the organoid-formation potential of cochlear cell types and show that greater epithelial ridge cells, adjacent to the neonatal organ of Corti, have the strongest potential. Single-cell transcriptomic analysis confirms the identities of all cochlear cell groups. Their findings advance cell-based assays for development of inner ear therapies.",

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AU - Jan, Taha A.

AU - Heller, Stefan

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AB - Kubota et al. compare the organoid-formation potential of cochlear cell types and show that greater epithelial ridge cells, adjacent to the neonatal organ of Corti, have the strongest potential. Single-cell transcriptomic analysis confirms the identities of all cochlear cell groups. Their findings advance cell-based assays for development of inner ear therapies.

KW - auditory periphery

KW - epigenetic reprogramming

KW - hair cell regeneration

KW - inner ear organoid

KW - otic

KW - supporting cell

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Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea

Abstract

Keywords

ASJC Scopus subject areas

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