Green tea polyphenols in drug discovery: A success or failure?

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Green tea is made from unfermented dried leaves from Camellia sinensis and has been consumed by humans for thousands of years. For nearly as long, it has been used as a folk remedy for a wide array of diseases. More recently, a large number of in vitro and in vivo scientific studies have supported this ancient contention that the polyphenols from green tea can provide a number of health benefits. As these compounds are clearly safe for human consumption and ubiquitous in the food supply, they are highly attractive as lead compounds for drug discovery programs. However, as drugs, they are far from optimum. They are relatively unstable, poorly absorbed, and readily undergo a number of metabolic transformations by intestinal microbiota and human enzymes. Further, as these compounds target a wide array of biological systems, in vivo testing is rather difficult as effects on alternative pathways need to be carefully eliminated. The purpose of this review is to discuss some of the challenges and benefits of pursuing this family of compounds for drug discovery.

Original languageEnglish (US)
Pages (from-to)589-595
Number of pages7
JournalExpert Opinion on Drug Discovery
Volume6
Issue number6
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

Keywords

  • catechins
  • drug discovery
  • green tea
  • insulin
  • polyphenols

ASJC Scopus subject areas

  • Drug Discovery

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