Group B streptococci elicit leukotriene B4and interleukin-8 from human monocytes: Neonates exhibit a diminished response

Judith L. Rowen, C. Wayne Smith, Morven S. Edwards

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Neonatal monocytes have diminished function compared with adult cells. The ability to recruit neutrophils through elaboration of chemoattractants has not been evaluated in humans. The pattern of chemoattractant release induced by group B streptococci (GBS) also is unknown. Adult and cord blood monocytes were stimulated with GBS. Supernatants were used as the attractant in blind well chambers; migration to neonatal supernatants was diminished. Interleukin-8 (IL-8) and leukotriene B4(LTB4) were released in greater quantities by adult monocytes in response to either GBS or lipopolysaccharide. Opsonization of GBS was not required for IL-8 release. Adult monocytes released more LTB4when stimulated with unopsonized GBS than with opsonized GBS; the neonate's LTB4 production did not increase. IL-8 and LTB4accounted for the majority of chemoattractant activity released in response to GBS. Decreased production of LTB4and IL-8 may contribute to the neonate's poor host response to GBS.

Original languageEnglish (US)
Pages (from-to)420-426
Number of pages7
JournalJournal of Infectious Diseases
Volume172
Issue number2
DOIs
StatePublished - Aug 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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