Growth factors

Local and systemic

David Herndon, T. T. Nguyen, D. A. Gilpin

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Growth factors that are produced locally at the wound site and systemically from distant sources may elicit inhibitory or stimulatory responses depending on interactions with other factors and the cellular environment into which they are liberated. Growth factors released from macrophages, neutrophils, lymphocytes, platelets, and fibroblasts bind to target cells via specific cell-surface receptors inducing cells to migrate, divide, or produce other factors required for wound healing. Structural similarities between cell receptors may explain cross-reactivity between substances. Systemic growth factors, such as growth hormone and local epidermal growth factor, fibroblast growth factor, platelet-derived growth factor, and transforming growth factor β have all been shown to enhance wound healing. Further, growth factors have been shown to have a distinct role in catabolic and malnourished patients as well as in patients with cancer. Clinical trials with growth factors have demonstrated efficacy, and specific uses for those particular factors may become an accepted mode of therapy producing important differences in outcome.

Original languageEnglish (US)
Pages (from-to)1227-1233
Number of pages7
JournalArchives of Surgery
Volume128
Issue number11
StatePublished - 1993

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Intercellular Signaling Peptides and Proteins
Wound Healing
Fibroblast Growth Factors
Platelet-Derived Growth Factor
Cell Surface Receptors
Transforming Growth Factors
Epidermal Growth Factor
Growth Hormone
Neutrophils
Blood Platelets
Fibroblasts
Macrophages
Clinical Trials
Lymphocytes
Wounds and Injuries
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Herndon, D., Nguyen, T. T., & Gilpin, D. A. (1993). Growth factors: Local and systemic. Archives of Surgery, 128(11), 1227-1233.

Growth factors : Local and systemic. / Herndon, David; Nguyen, T. T.; Gilpin, D. A.

In: Archives of Surgery, Vol. 128, No. 11, 1993, p. 1227-1233.

Research output: Contribution to journalArticle

Herndon, D, Nguyen, TT & Gilpin, DA 1993, 'Growth factors: Local and systemic', Archives of Surgery, vol. 128, no. 11, pp. 1227-1233.
Herndon D, Nguyen TT, Gilpin DA. Growth factors: Local and systemic. Archives of Surgery. 1993;128(11):1227-1233.
Herndon, David ; Nguyen, T. T. ; Gilpin, D. A. / Growth factors : Local and systemic. In: Archives of Surgery. 1993 ; Vol. 128, No. 11. pp. 1227-1233.
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