Growth Hormone Alters Brain Morphometry, Connectivity, and Behavior in Subjects with Fatigue after Mild Traumatic Brain Injury

Traver Wright, Randall Urban, William Durham, E. Lichar Dillon, Kathleen M. Randolph, Christopher Danesi, Charles Gilkison, Christof Karmonik, Dennis Zgaljardic, Brent Masel, James Bishop, Richard Pyles, Rachael Seidler, Ashton H. Hierholzer, Melinda Moore

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Pituitary dysfunction with reduced growth hormone (GH) secretion is common in patients following traumatic brain injury (TBI), and these patients often develop chronic symptoms including fatigue and altered cognition. We examined 18 subjects with a history of mild TBI, fatigue, and insufficient GH secretion. Subjects received GH replacement in a year-long, double-blind, placebo-controlled, crossover study, and were assessed for changes in physical performance, body composition, resting energy expenditure, fatigue, sleep, mood, and neuropsychological status. Additionally, magnetic resonance imaging (MRI) was used to assess changes in brain structure and resting state functional connectivity. GH replacement resulted in decreased fatigue, sleep disturbance, and anxiety, as well as increased resting energy expenditure, improved body composition, and altered perception of submaximal effort when performing exercise testing. Associated brain changes included increased frontal cortical thickness and gray matter volume and resting state connectivity changes in regions associated with somatosensory networks. GH replacement altered brain morphology and connectivity and reduced fatigue and related symptoms in mild TBI patients. Additional studies are needed to understand the mechanisms causing TBI-related fatigue and symptom relief with GH replacement.

Original languageEnglish (US)
Pages (from-to)1052-1066
Number of pages15
JournalJournal of neurotrauma
Volume37
Issue number8
DOIs
StatePublished - Apr 15 2020

Keywords

  • GH
  • TBI
  • fatigue

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Growth Hormone Alters Brain Morphometry, Connectivity, and Behavior in Subjects with Fatigue after Mild Traumatic Brain Injury'. Together they form a unique fingerprint.

  • Cite this

    Wright, T., Urban, R., Durham, W., Dillon, E. L., Randolph, K. M., Danesi, C., Gilkison, C., Karmonik, C., Zgaljardic, D., Masel, B., Bishop, J., Pyles, R., Seidler, R., Hierholzer, A. H., & Moore, M. (2020). Growth Hormone Alters Brain Morphometry, Connectivity, and Behavior in Subjects with Fatigue after Mild Traumatic Brain Injury. Journal of neurotrauma, 37(8), 1052-1066. https://doi.org/10.1089/neu.2019.6690