Abstract
The use of exogenous GH to increase its circulating concentration, may benefit critically ill patients by increasing their nitrogen retention and promoting the wound healing process. GH also changes protein production in wounds, causes higher levels of insulin and changes substrate utilization. Its effects are anabolic, diabetogenic and lipolytic, acting through both direct and indirect mechanisms. The effects on carbohydrate and fat metabolism are directly mediated through specific GH receptors, while its effect on protein is mediated through IGF-I. Its effects on IGF-I production and the induction of IGF binding proteins are currently being studied in an effort to better understand the mechanism of GH actions during stress.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 447-463 |
| Number of pages | 17 |
| Journal | Bailliere's Clinical Endocrinology and Metabolism |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Biochemistry
Cite this
Growth hormone and IGF-I therapy in the hypercatabolic patient. / Wolf, Steven; Barrow, R. E.; Herndon, David.
In: Bailliere's Clinical Endocrinology and Metabolism, Vol. 10, No. 3, 1996, p. 447-463.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Growth hormone and IGF-I therapy in the hypercatabolic patient
AU - Wolf, Steven
AU - Barrow, R. E.
AU - Herndon, David
PY - 1996
Y1 - 1996
N2 - The use of exogenous GH to increase its circulating concentration, may benefit critically ill patients by increasing their nitrogen retention and promoting the wound healing process. GH also changes protein production in wounds, causes higher levels of insulin and changes substrate utilization. Its effects are anabolic, diabetogenic and lipolytic, acting through both direct and indirect mechanisms. The effects on carbohydrate and fat metabolism are directly mediated through specific GH receptors, while its effect on protein is mediated through IGF-I. Its effects on IGF-I production and the induction of IGF binding proteins are currently being studied in an effort to better understand the mechanism of GH actions during stress.
AB - The use of exogenous GH to increase its circulating concentration, may benefit critically ill patients by increasing their nitrogen retention and promoting the wound healing process. GH also changes protein production in wounds, causes higher levels of insulin and changes substrate utilization. Its effects are anabolic, diabetogenic and lipolytic, acting through both direct and indirect mechanisms. The effects on carbohydrate and fat metabolism are directly mediated through specific GH receptors, while its effect on protein is mediated through IGF-I. Its effects on IGF-I production and the induction of IGF binding proteins are currently being studied in an effort to better understand the mechanism of GH actions during stress.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029774283&partnerID=8YFLogxK
U2 - 10.1016/S0950-351X(96)80575-1
DO - 10.1016/S0950-351X(96)80575-1
M3 - Article
VL - 10
SP - 447
EP - 463
JO - Bailliere's Clinical Endocrinology and Metabolism
JF - Bailliere's Clinical Endocrinology and Metabolism
SN - 0950-351X
IS - 3
ER -