Growth hormone and insulin reverse net whole body and skeletal muscle protein catabolism in cancer patients

R. F. Wolf, D. B. Pearlstone, E. Newman, M. J. Heslin, A. Gonenne, M. E. Burt, M. F. Brennan, D. N. Herndon, D. W. Wilmore, S. Lowry, W. S. Blakemore

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68 Scopus citations

Abstract

The authors examined the effect of recombinant-human growth hormone (r- hGH) and insulin (INS) administration on protein kinetics in cancer patients. Twenty-eight cancer patients either received r-hGH for 3 days (GH group, n = 12, weight loss = 6 ± 2%) or were not treated (control [CTL] group, n = 16, weight loss = 11 ± 2%) before metabolic study. Recombinant-human growth hormone dose was 0.1 mg/kg/day (n = 6) or 0.2 mg/kg/day (n = 6). Patients then underwent measurement of baseline protein kinetics (GH/B, CTL/B) followed by a 2-hour euglycemic insulin infusion (1 mU/kg/minute) and repeat kinetic measurements (GH/INS,CTL/INS). Whole-body protein net balance (μmol leucine/kg/minute) was higher (p < 0.05) in GH/INS (0.20 ± 0.06) than in CTL/INS (0.06 ± 0.03) or GH/B (-0.19 ± 0.03). Skeletal muscle protein net balance (nmol phenylalanine/100 g/minute) in GH/INS (25 ± 6) and CTL/INS (19 ± 5) was higher than CTL/B (-18 ± 3). Recombinant-human growth hormone and insulin reduce whole-body and skeletal muscle protein loss in cancer patients. Simultaneous use of these agents during nutritional therapy may benefit the cancer patient.

Original languageEnglish (US)
Pages (from-to)280-290
Number of pages11
JournalAnnals of surgery
Volume216
Issue number3
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Surgery

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    Wolf, R. F., Pearlstone, D. B., Newman, E., Heslin, M. J., Gonenne, A., Burt, M. E., Brennan, M. F., Herndon, D. N., Wilmore, D. W., Lowry, S., & Blakemore, W. S. (1992). Growth hormone and insulin reverse net whole body and skeletal muscle protein catabolism in cancer patients. Annals of surgery, 216(3), 280-290. https://doi.org/10.1097/00000658-199209000-00007