Growth hormone and oxandrolone in burned children

Nigel Tapiwa Mabvuure, Alexis N. Thomas, Linda Sousse

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Children with large burns exhibit a hypermetabolic state, often resulting in bone loss and growth velocity impairment. The hypothesis that anabolic drugs may counteract bone loss is based on observations made from using these drugs in conditions of short stature such as Turner's syndrome. Two anabolic agents that have been used successfully in these settings are exogenous human growth hormone and oxandrolone, a testosterone analogue. In this chapter, we review the literature that demonstrates that the administration of these two drugs in burned children is both safe and efficacious in improving post-burn bone health outcomes. The systemic action of these anabolic agents beyond the bone metabolic system has also been explored in the clinical trials described. However, only bone-related markers are discussed in detail in this chapter.

Original languageEnglish (US)
Title of host publicationBone Drugs in Pediatrics: Efficacy and Challenges
PublisherSpringer US
Pages135-152
Number of pages18
Volume9781489974365
ISBN (Print)9781489974365, 1489974350, 9781489974358
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

Fingerprint

Oxandrolone
Growth Hormone
Anabolic Agents
Bone and Bones
Burns
Pharmaceutical Preparations
Turner Syndrome
Human Growth Hormone
Bone Development
Testosterone
Clinical Trials
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mabvuure, N. T., Thomas, A. N., & Sousse, L. (2014). Growth hormone and oxandrolone in burned children. In Bone Drugs in Pediatrics: Efficacy and Challenges (Vol. 9781489974365, pp. 135-152). Springer US. https://doi.org/10.1007/978-1-4899-7436-5_9

Growth hormone and oxandrolone in burned children. / Mabvuure, Nigel Tapiwa; Thomas, Alexis N.; Sousse, Linda.

Bone Drugs in Pediatrics: Efficacy and Challenges. Vol. 9781489974365 Springer US, 2014. p. 135-152.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mabvuure, NT, Thomas, AN & Sousse, L 2014, Growth hormone and oxandrolone in burned children. in Bone Drugs in Pediatrics: Efficacy and Challenges. vol. 9781489974365, Springer US, pp. 135-152. https://doi.org/10.1007/978-1-4899-7436-5_9
Mabvuure NT, Thomas AN, Sousse L. Growth hormone and oxandrolone in burned children. In Bone Drugs in Pediatrics: Efficacy and Challenges. Vol. 9781489974365. Springer US. 2014. p. 135-152 https://doi.org/10.1007/978-1-4899-7436-5_9
Mabvuure, Nigel Tapiwa ; Thomas, Alexis N. ; Sousse, Linda. / Growth hormone and oxandrolone in burned children. Bone Drugs in Pediatrics: Efficacy and Challenges. Vol. 9781489974365 Springer US, 2014. pp. 135-152
@inbook{ac3e77bdf2394c2996905f5e11a74e45,
title = "Growth hormone and oxandrolone in burned children",
abstract = "Children with large burns exhibit a hypermetabolic state, often resulting in bone loss and growth velocity impairment. The hypothesis that anabolic drugs may counteract bone loss is based on observations made from using these drugs in conditions of short stature such as Turner's syndrome. Two anabolic agents that have been used successfully in these settings are exogenous human growth hormone and oxandrolone, a testosterone analogue. In this chapter, we review the literature that demonstrates that the administration of these two drugs in burned children is both safe and efficacious in improving post-burn bone health outcomes. The systemic action of these anabolic agents beyond the bone metabolic system has also been explored in the clinical trials described. However, only bone-related markers are discussed in detail in this chapter.",
author = "Mabvuure, {Nigel Tapiwa} and Thomas, {Alexis N.} and Linda Sousse",
year = "2014",
month = "2",
day = "1",
doi = "10.1007/978-1-4899-7436-5_9",
language = "English (US)",
isbn = "9781489974365",
volume = "9781489974365",
pages = "135--152",
booktitle = "Bone Drugs in Pediatrics: Efficacy and Challenges",
publisher = "Springer US",

}

TY - CHAP

T1 - Growth hormone and oxandrolone in burned children

AU - Mabvuure, Nigel Tapiwa

AU - Thomas, Alexis N.

AU - Sousse, Linda

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Children with large burns exhibit a hypermetabolic state, often resulting in bone loss and growth velocity impairment. The hypothesis that anabolic drugs may counteract bone loss is based on observations made from using these drugs in conditions of short stature such as Turner's syndrome. Two anabolic agents that have been used successfully in these settings are exogenous human growth hormone and oxandrolone, a testosterone analogue. In this chapter, we review the literature that demonstrates that the administration of these two drugs in burned children is both safe and efficacious in improving post-burn bone health outcomes. The systemic action of these anabolic agents beyond the bone metabolic system has also been explored in the clinical trials described. However, only bone-related markers are discussed in detail in this chapter.

AB - Children with large burns exhibit a hypermetabolic state, often resulting in bone loss and growth velocity impairment. The hypothesis that anabolic drugs may counteract bone loss is based on observations made from using these drugs in conditions of short stature such as Turner's syndrome. Two anabolic agents that have been used successfully in these settings are exogenous human growth hormone and oxandrolone, a testosterone analogue. In this chapter, we review the literature that demonstrates that the administration of these two drugs in burned children is both safe and efficacious in improving post-burn bone health outcomes. The systemic action of these anabolic agents beyond the bone metabolic system has also been explored in the clinical trials described. However, only bone-related markers are discussed in detail in this chapter.

UR - http://www.scopus.com/inward/record.url?scp=84929692960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929692960&partnerID=8YFLogxK

U2 - 10.1007/978-1-4899-7436-5_9

DO - 10.1007/978-1-4899-7436-5_9

M3 - Chapter

SN - 9781489974365

SN - 1489974350

SN - 9781489974358

VL - 9781489974365

SP - 135

EP - 152

BT - Bone Drugs in Pediatrics: Efficacy and Challenges

PB - Springer US

ER -