Growth hormone and testosterone: Anabolic effects on muscle

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background: The loss of skeletal muscle mass that occurs with aging, chronic disease or acute injury is clinically important in the health of humans. The mechanisms relating to the synthesis and breakdown of skeletal muscle are now being intensely investigated. Current studies and possible mechanisms for skeletal muscle protein synthesis and degradation will be reviewed with a specific focus on growth hormone and testosterone. Conclusions:Investigation of the mechanisms of action of growth hormone and testosterone in skeletal muscle will likely lead to new therapies to prevent skeletal muscle loss and new awareness of the importance of skeletal muscle in health and disease.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalHormone Research in Paediatrics
Volume76
Issue numberSUPPL. 1
DOIs
StatePublished - Jul 1 2011

Keywords

  • Growth hormone
  • Sarcopenia
  • Skeletal muscle protein synthesis
  • Testosterone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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