Growth hormone therapy in the elderly

Implications for the aging brain

Andrew R. Hoffman, Steven Lieberman, Gian Paolo Ceda

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Growth hormone (GH) secretion declines during normal aging, resulting in lower serum insulin-like growth factor (IGF)-I levels. It has been proposed that many of the catabolic changes seen in normal aging, including osteoporosis and muscle atrophy, are in part caused by the decreased action of the GH-IGF-I axis. In addition, patients with GH deficiency have increased overall cardiovascular mortality. Several investigators have initiated GH treatment for elderly patients with relative hyposomatotropinemia. Initial receptors suggest that GH can increase muscle mass, improve exercise tolerance, increase REM sleep and cause an enhanced sense of well-being. The basis for neuropsychiatric changes during GH therapy may be due to a direct CNS action of GH itself, to the increased IGF-I secretion which GH elicits, or to enhanced functioning of peripheral organ systems. Long-term studies will determine whether GH or IGF-I can exert a neurotrophic action in the aging brain.

Original languageEnglish (US)
Pages (from-to)327-333
Number of pages7
JournalPsychoneuroendocrinology
Volume17
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Growth Hormone
Brain
Insulin-Like Growth Factor I
Therapeutics
Somatotropin Receptors
Exercise Tolerance
Muscular Atrophy
REM Sleep
Osteoporosis
Research Personnel
Muscles
Mortality
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

Growth hormone therapy in the elderly : Implications for the aging brain. / Hoffman, Andrew R.; Lieberman, Steven; Ceda, Gian Paolo.

In: Psychoneuroendocrinology, Vol. 17, No. 4, 1992, p. 327-333.

Research output: Contribution to journalArticle

Hoffman, Andrew R. ; Lieberman, Steven ; Ceda, Gian Paolo. / Growth hormone therapy in the elderly : Implications for the aging brain. In: Psychoneuroendocrinology. 1992 ; Vol. 17, No. 4. pp. 327-333.
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